Biocompatibility of porous silicon for biomedical applications

D. Liu, M.-A. Shahbazi, L.M. Bimbo, J. Hirvonen, H. A. Santos

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Advanced drug delivery technologies have emerged as an important focus of biomedical research. Despite the design and effectiveness of the technology, the nature of its interactions with surrounding tissues – their biocompatibility – is of utmost importance. Porous silicon (PSi) possesses unique physicochemical properties that are advantageous for biomedical applications. Despite the increase in the prevalence of engineered materials and the large number of studies found in the literature, little is still known about their safety and potential impact on human health. This chapter provides an overview of the aspects of biocompatibility and the assays used to assess the toxicity of PSi-based materials on cells (in vitro) and organs/tissues (in vivo). We summarize the continuing efforts for understanding the factors affecting biocompatibility of PSi-based materials. Several assessment techniques and methods are described and discussed herein.
Original languageEnglish
Title of host publicationPorous Silicon For Biomedical Applications
EditorsHélder A. Santos
Place of PublicationCambridge
Pages129-181
Number of pages53
Volume68
DOIs
Publication statusPublished - 25 Feb 2014
Externally publishedYes

Publication series

NameWoodhead Publishing Series in Biomaterials
PublisherWoodhead Publishing Ltd.
Number68

Keywords

  • drug delivery
  • porous silicon
  • biomedical applications
  • biocompatibility
  • toxicity
  • biodegradability
  • bioassays
  • particles

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  • Cite this

    Liu, D., Shahbazi, M-A., Bimbo, L. M., Hirvonen, J., & Santos, H. A. (2014). Biocompatibility of porous silicon for biomedical applications. In H. A. Santos (Ed.), Porous Silicon For Biomedical Applications (Vol. 68, pp. 129-181). (Woodhead Publishing Series in Biomaterials; No. 68).. https://doi.org/10.1533/9780857097156.1.129