Biocatalytically triggered co-assembly of two-component core/shell nanofibers

Yousef M Abul-Haija, Sangita Roy, Pim W J M Frederix, Nadeem Javid, Vineetha Jayawarna, Rein V Ulijn

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)
165 Downloads (Pure)


For the development of applications and novel uses for peptide nanostructures, robust routes for their surface functionalization, that ideally do not interfere with their self-assembly properties, are required. Many existing methods rely on covalent functionalization, where building blocks are appended with functional groups, either pre- or post-assembly. A facile supramolecular approach is demonstrated for the formation of functionalized nanofibers by combining the advantages of biocatalytic self-assembly and surfactant/gelator co-assembly. This is achieved by enzymatically triggered reconfiguration of free flowing micellar aggregates of pre-gelators and functional surfactants to form nanofibers that incorporate and display the surfactants' functionality at the surface. Furthermore, by varying enzyme concentration, the gel stiffness and supramolecular organization of building blocks can be varied.
Original languageEnglish
Number of pages24
Early online date11 Sep 2013
Publication statusE-pub ahead of print - 11 Sep 2013


  • biocatalysis
  • co-assembly
  • peptides
  • surface functionality
  • transformation


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