Biocatalytic self-assembly using reversible and irreversible enzyme immobilization

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Biocatalytic control of molecular self-assembly provides an effective approach for developing smart biomaterials, allowing versatile enzyme-mediated tuning of material structure and properties as well as biomedical applications. We functionalized surfaces with bioinspired polydopamine and polyphenol coatings to study the effects of enzyme surface localization and surface release on the self-assembly process. We show how these coatings could be conveniently used to release enzymes for bulk gelation as well as to irreversibly immobilize enzymes for localizing the self-assembly to the surface. The results provide insights to the mode of action of biocatalytic self-assembly relevant to nanofabrication and enzyme-responsive materials.
Original languageEnglish
Pages (from-to)3266-3271
Number of pages6
JournalACS Applied Materials and Interfaces
Issue number4
Early online date12 Jan 2017
Publication statusPublished - 1 Feb 2017


  • supramolecular chemistry
  • polydopamine
  • polyphenol
  • protein
  • bioinspired mateerial
  • surface functionalization
  • biointerfaces
  • hydrogel


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