Biocatalytic ATRP: controlled radical polymerizations mediated by enzymes

Kasper Renggli, Mariana Spulber, Jonas Pollard, Martin Rother, Nico Bruns

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

3 Citations (Scopus)


The advent of controlled radical polymerizations has made polymer science a key discipline for the preparation of nano-, biomedical-, and high tech-materials. Atom transfer radical polymerization (ATRP) is one of the most widely applied controlled radical polymerization. However, an ongoing quest is to develop ATRP reaction conditions that allow reducing the amount of catalyst needed, or to replace the currently used transition metal complex catalysts with less toxic ones. Using enzymes as catalysts is a classic strategy in the green chemistry approach, and many enzymatic polymerizations are known. However, controlled radical polymerizations that are catalyzed by enzymes or proteins were not known until our discovery that the metalloproteins horseradish peroxidase and hemoglobin can polymerize vinyl-monomers under conditions of activators regenerated by electron transfer (ARGET) ATRP. In this book chapter, we review the emerging field of biocatalytic ATRP.

Original languageEnglish
Title of host publicationGreen Polymer Chem
Subtitle of host publicationBiocatalysis and Materials II
PublisherAmerican Chemical Society
Number of pages9
ISBN (Print)9780841228955
Publication statusPublished - 1 Jan 2013

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918


  • enzymatic polymerization
  • catalysts
  • enzymes
  • free radical polymerization
  • functional polymers
  • metal complexes
  • proteins
  • transition metal compounds
  • atom transfer radical polymerization
  • green chemistry approaches


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