Biocatalytic ATRP

Jonas Pollard; Nico Bruns

doi:10.1021/bk-2018-1284.ch019

Biocatalytic ATRP

Jonas Pollard, Nico Bruns

Pure And Applied Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

1 Citation (Scopus)

Abstract

Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

Original language	English
Title of host publication	Reversible Deactivation Radical Polymerization
Subtitle of host publication	Mechanisms and Synthetic Methodologies
Editors	Nicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin
Publisher	American Chemical Society
Pages	379-393
Number of pages	15
Volume	1284
ISBN (Print)	9780841233188
DOIs	https://doi.org/10.1021/bk-2018-1284.ch019
Publication status	Published - 1 Jan 2018

Publication series

Name	ACS Symposium Series
Volume	1284
ISSN (Print)	0097-6156
ISSN (Electronic)	1947-5918

Keywords

enzymes
free radical reactions
living polymerization
porphyrins
atom transfer radical polymerization
enzyme mimetics
lipases

Access to Document

10.1021/bk-2018-1284.ch019

Link to publication in Scopus

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title = "Biocatalytic ATRP",

abstract = "Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how {"}ATRPases{"} and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.",

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Biocatalytic ATRP. / Pollard, Jonas; Bruns, Nico.

Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ed. / Nicolay V. Tsarevsky; Haifeng Gao; Krzysztof Matyjaszewski; Brent S. Sumerlin. Vol. 1284 American Chemical Society, 2018. p. 379-393 (ACS Symposium Series; Vol. 1284).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

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AU - Pollard, Jonas

AU - Bruns, Nico

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

AB - Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

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KW - free radical reactions

KW - living polymerization

KW - porphyrins

KW - atom transfer radical polymerization

KW - enzyme mimetics

KW - lipases

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