Biocatalytic ATRP

Jonas Pollard, Nico Bruns

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

4 Citations (Scopus)


Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

Original languageEnglish
Title of host publicationReversible Deactivation Radical Polymerization
Subtitle of host publicationMechanisms and Synthetic Methodologies
EditorsNicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin
PublisherAmerican Chemical Society
Number of pages15
ISBN (Print)9780841233188
Publication statusPublished - 1 Jan 2018

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918


  • enzymes
  • free radical reactions
  • living polymerization
  • porphyrins
  • atom transfer radical polymerization
  • enzyme mimetics
  • lipases


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