Abstract
Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.
| Original language | English |
|---|---|
| Title of host publication | Reversible Deactivation Radical Polymerization |
| Subtitle of host publication | Mechanisms and Synthetic Methodologies |
| Editors | Nicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin |
| Publisher | American Chemical Society |
| Pages | 379-393 |
| Number of pages | 15 |
| Volume | 1284 |
| ISBN (Print) | 9780841233188 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Publication series
| Name | ACS Symposium Series |
|---|---|
| Volume | 1284 |
| ISSN (Print) | 0097-6156 |
| ISSN (Electronic) | 1947-5918 |
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Keywords
- enzymes
- free radical reactions
- living polymerization
- porphyrins
- atom transfer radical polymerization
- enzyme mimetics
- lipases
Cite this
}
Biocatalytic ATRP. / Pollard, Jonas; Bruns, Nico.
Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ed. / Nicolay V. Tsarevsky; Haifeng Gao; Krzysztof Matyjaszewski; Brent S. Sumerlin. Vol. 1284 American Chemical Society, 2018. p. 379-393 (ACS Symposium Series; Vol. 1284).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
TY - CHAP
T1 - Biocatalytic ATRP
AU - Pollard, Jonas
AU - Bruns, Nico
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.
AB - Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.
KW - enzymes
KW - free radical reactions
KW - living polymerization
KW - porphyrins
KW - atom transfer radical polymerization
KW - enzyme mimetics
KW - lipases
UR - http://www.scopus.com/inward/record.url?scp=85052812903&partnerID=8YFLogxK
U2 - 10.1021/bk-2018-1284.ch019
DO - 10.1021/bk-2018-1284.ch019
M3 - Chapter (peer-reviewed)
AN - SCOPUS:85052812903
SN - 9780841233188
VL - 1284
T3 - ACS Symposium Series
SP - 379
EP - 393
BT - Reversible Deactivation Radical Polymerization
A2 - Tsarevsky, Nicolay V.
A2 - Gao, Haifeng
A2 - Matyjaszewski, Krzysztof
A2 - Sumerlin, Brent S.
PB - American Chemical Society
ER -