Biocatalytic ATRP

Jonas Pollard, Nico Bruns

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

Original languageEnglish
Title of host publicationReversible Deactivation Radical Polymerization
Subtitle of host publicationMechanisms and Synthetic Methodologies
EditorsNicolay V. Tsarevsky, Haifeng Gao, Krzysztof Matyjaszewski, Brent S. Sumerlin
PublisherAmerican Chemical Society
Pages379-393
Number of pages15
Volume1284
ISBN (Print)9780841233188
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameACS Symposium Series
Volume1284
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Fingerprint

Atom transfer radical polymerization
Hemin
Enzymes
Heme
Catalysts
Polymerization
Nanoreactors
Laccase
Hemoglobin
Coenzymes
Horseradish Peroxidase
Biosensors
Catalase
Peptides
Copper
Polymers
Hemoglobins
Genes
Nanoparticles

Keywords

  • enzymes
  • free radical reactions
  • living polymerization
  • porphyrins
  • atom transfer radical polymerization
  • enzyme mimetics
  • lipases

Cite this

Pollard, J., & Bruns, N. (2018). Biocatalytic ATRP. In N. V. Tsarevsky, H. Gao, K. Matyjaszewski, & B. S. Sumerlin (Eds.), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies (Vol. 1284, pp. 379-393). (ACS Symposium Series; Vol. 1284). American Chemical Society. https://doi.org/10.1021/bk-2018-1284.ch019
Pollard, Jonas ; Bruns, Nico. / Biocatalytic ATRP. Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. editor / Nicolay V. Tsarevsky ; Haifeng Gao ; Krzysztof Matyjaszewski ; Brent S. Sumerlin. Vol. 1284 American Chemical Society, 2018. pp. 379-393 (ACS Symposium Series).
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Pollard, J & Bruns, N 2018, Biocatalytic ATRP. in NV Tsarevsky, H Gao, K Matyjaszewski & BS Sumerlin (eds), Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. vol. 1284, ACS Symposium Series, vol. 1284, American Chemical Society, pp. 379-393. https://doi.org/10.1021/bk-2018-1284.ch019

Biocatalytic ATRP. / Pollard, Jonas; Bruns, Nico.

Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. ed. / Nicolay V. Tsarevsky; Haifeng Gao; Krzysztof Matyjaszewski; Brent S. Sumerlin. Vol. 1284 American Chemical Society, 2018. p. 379-393 (ACS Symposium Series; Vol. 1284).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AB - Enzymes, their cofactors as well as enzyme mimetics can catalyze atom transfer radical polymerization (ATRP). Catalysts for this bioATRP are heme enzymes such as horseradish peroxidase, hemoglobin, and catalase, as well as the copper-containing laccases. Moreover, hemin, PEGylated hemin, heme-peptide conjugates, and single-chain polymer nanoparticles have been explored as ATRP catalysts. This chapter reviews biocatalytic ATRP as well as biocatalytically initiated RAFT polymerizations, and shows how "ATRPases" and other biologically derived catalysts are used, e.g., to tune well-controlled surface-initiated polymerizations, to confine ATRP into nanoreactors, and to prepare non-viral gene vectors or biosensors.

KW - enzymes

KW - free radical reactions

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KW - enzyme mimetics

KW - lipases

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Pollard J, Bruns N. Biocatalytic ATRP. In Tsarevsky NV, Gao H, Matyjaszewski K, Sumerlin BS, editors, Reversible Deactivation Radical Polymerization: Mechanisms and Synthetic Methodologies. Vol. 1284. American Chemical Society. 2018. p. 379-393. (ACS Symposium Series). https://doi.org/10.1021/bk-2018-1284.ch019