Biocatalytic amide condensation and gelation controlled by light

Jugal Kishore Sahoo, Siva Krishna Mohan Nalluri, Nadeem Javid, Hannah Webb, Rein V. Ulijn

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans- in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis- + ) with consequent gel dissolution.

LanguageEnglish
Pages5462-5464
Number of pages3
JournalChemical Communications
Volume50
Issue number41
DOIs
Publication statusPublished - 24 Apr 2014

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Gelation
Amides
Condensation
Ultraviolet radiation
Isomers
Self assembly
Peptides
Amino acids
Hydrolysis
Dissolution
Peptide Hydrolases
Gels
Irradiation
Derivatives
Amino Acids

Keywords

  • peptides
  • gelation
  • gels
  • biocatalytic condensation

Cite this

Sahoo, Jugal Kishore ; Nalluri, Siva Krishna Mohan ; Javid, Nadeem ; Webb, Hannah ; Ulijn, Rein V. / Biocatalytic amide condensation and gelation controlled by light. In: Chemical Communications. 2014 ; Vol. 50, No. 41. pp. 5462-5464.
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Biocatalytic amide condensation and gelation controlled by light. / Sahoo, Jugal Kishore; Nalluri, Siva Krishna Mohan; Javid, Nadeem; Webb, Hannah; Ulijn, Rein V.

In: Chemical Communications, Vol. 50, No. 41, 24.04.2014, p. 5462-5464.

Research output: Contribution to journalArticle

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AU - Sahoo, Jugal Kishore

AU - Nalluri, Siva Krishna Mohan

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AU - Ulijn, Rein V.

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