Biocatalytic amide condensation and gelation controlled by light

Jugal Kishore Sahoo, Siva Krishna Mohan Nalluri, Nadeem Javid, Hannah Webb, Rein V. Ulijn

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans- in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis- + ) with consequent gel dissolution.

Original languageEnglish
Pages (from-to)5462-5464
Number of pages3
JournalChemical Communications
Volume50
Issue number41
DOIs
Publication statusPublished - 24 Apr 2014

Keywords

  • peptides
  • gelation
  • gels
  • biocatalytic condensation

Fingerprint Dive into the research topics of 'Biocatalytic amide condensation and gelation controlled by light'. Together they form a unique fingerprint.

Cite this