Biocatalytic alkylation cascades: recent advances and future opportunities for late-stage functionalization

Research output: Contribution to journalArticle

Abstract

This Concept article describes the latest developments in the emerging area of late-stage biocatalytic alkylation. Central to these developments is the ability to efficiently prepare S-adenosyl methionine (SAM) cofactor analogues and couple this with enzymatic alkyl transfer. Recent developments in the enzymatic synthesis of SAM cofactor analogues are summarized first, followed by their application as alkyl transfer agents catalyzed by methyltransferases (MTases). Second, innovative methods to regenerate SAM cofactors by enzymatic cascades is reported. Finally, future opportunities towards establishing a generalized platform for late-stage alkylation are described.

Original languageEnglish
JournalChembiochem
Early online date27 May 2020
DOIs
Publication statusE-pub ahead of print - 27 May 2020

Keywords

  • alkylation
  • biocatalysis
  • cascades
  • regeneration
  • S-adenosyl methionine

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