Bioaffinity detection of pathogens on surfaces

Alastair Wark, J. Lee, S. Kim, S. N. Faisal, H. J. Lee

Research output: Contribution to journalLiterature reviewpeer-review

19 Citations (Scopus)
327 Downloads (Pure)

Abstract

The demand for improved technologies capable of rapidly detecting pathogens with high sensitivity and selectivity in complex environments continues to be a significant challenge that helps drive the development of new analytical techniques. Surface-based detection platforms are particularly attractive
as multiple bioaffinity interactions between different targets and corresponding probe molecules can be monitored simultaneously in a single measurement. Furthermore, the possibilities for developing new signal transduction mechanisms alongside novel signal amplification strategies aremuchmore varied. In this article, we describe some of the latest advances in the use of surface bioaffinity detection of pathogens. Three major sections will be discussed: (i) a brief overview on the choice of probe molecules such as antibodies, proteins and aptamers specific to pathogens and surface attachment chemistries to immobilize those probes onto various substrates, (ii) highlighting examples among the current generation of surface biosensors, and (iii) exploring emerging technologies that are highly promising and likely to form the basis of the next generation of pathogenic sensors.
Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
Volume16
DOIs
Publication statusPublished - Jan 2010

Keywords

  • pathogens
  • bioaffinity sensing

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