Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

Adbessamad Debbab; Amal H. Aly; RuAngelie Edrada-Ebel; W.E.G. Mueller; Mahjouba Mosaddak; Adbelhak Hakikj; R. Ebel; Peter Proksch

Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

Adbessamad Debbab, Amal H. Aly, RuAngelie Edrada-Ebel, W.E.G. Mueller, Mahjouba Mosaddak, Adbelhak Hakikj, R. Ebel, Peter Proksch

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

392 Downloads (Pure)

Abstract

This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain in Morocco and belongs to the Lamiaceae family and is named in Morocco 'Salmia'. The endophytic fungus Chaetomium sp. was isolated from the tissues of the stem of this plant. The fungal strain was identified by PCR. The crude organic extract of the fungal strain was proven to be active when tested for cytotoxicity against L5178Y mouse lymphoma cells. Chemical investigation of the secondary metabolites showed that cochliodinol is the main component beside isocochliodinol. The structures of the isolated compounds were determined on the basis of NMR analysis (1H, 13C, COSY and HMBC) as well as by mass spectrometry using ESI (Electron Spray Ionisation) as source.

Original language	English
Pages (from-to)	229-234
Number of pages	5
Journal	Biotechnology, Agronomy, Society and Environment (BASE)
Volume	13
Issue number	2
Publication status	Published - 2009

Keywords

salvia officinalis
endophytic fungi
chaetomium
secondary metabolites
cochliodinol
spectroscopy
cytotoxicity
morocco

Access to Document

strathprints026015.pdf

Cite this

@article{1bc129f876134515801dae0fed40b846,

title = "Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco",

abstract = "This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain in Morocco and belongs to the Lamiaceae family and is named in Morocco 'Salmia'. The endophytic fungus Chaetomium sp. was isolated from the tissues of the stem of this plant. The fungal strain was identified by PCR. The crude organic extract of the fungal strain was proven to be active when tested for cytotoxicity against L5178Y mouse lymphoma cells. Chemical investigation of the secondary metabolites showed that cochliodinol is the main component beside isocochliodinol. The structures of the isolated compounds were determined on the basis of NMR analysis (1H, 13C, COSY and HMBC) as well as by mass spectrometry using ESI (Electron Spray Ionisation) as source.",

keywords = "salvia officinalis, endophytic fungi, chaetomium, secondary metabolites, cochliodinol, spectroscopy, cytotoxicity, morocco",

author = "Adbessamad Debbab and Aly, {Amal H.} and RuAngelie Edrada-Ebel and W.E.G. Mueller and Mahjouba Mosaddak and Adbelhak Hakikj and R. Ebel and Peter Proksch",

note = "Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.",

year = "2009",

language = "English",

volume = "13",

pages = "229--234",

journal = "Biotechnology, Agronomy, Society and Environment (BASE)",

issn = "1370-6233",

number = "2",

}

TY - JOUR

T1 - Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

AU - Debbab, Adbessamad

AU - Aly, Amal H.

AU - Edrada-Ebel, RuAngelie

AU - Mueller, W.E.G.

AU - Mosaddak, Mahjouba

AU - Hakikj, Adbelhak

AU - Ebel, R.

AU - Proksch, Peter

N1 - Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.

PY - 2009

Y1 - 2009

N2 - This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain in Morocco and belongs to the Lamiaceae family and is named in Morocco 'Salmia'. The endophytic fungus Chaetomium sp. was isolated from the tissues of the stem of this plant. The fungal strain was identified by PCR. The crude organic extract of the fungal strain was proven to be active when tested for cytotoxicity against L5178Y mouse lymphoma cells. Chemical investigation of the secondary metabolites showed that cochliodinol is the main component beside isocochliodinol. The structures of the isolated compounds were determined on the basis of NMR analysis (1H, 13C, COSY and HMBC) as well as by mass spectrometry using ESI (Electron Spray Ionisation) as source.

AB - This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain in Morocco and belongs to the Lamiaceae family and is named in Morocco 'Salmia'. The endophytic fungus Chaetomium sp. was isolated from the tissues of the stem of this plant. The fungal strain was identified by PCR. The crude organic extract of the fungal strain was proven to be active when tested for cytotoxicity against L5178Y mouse lymphoma cells. Chemical investigation of the secondary metabolites showed that cochliodinol is the main component beside isocochliodinol. The structures of the isolated compounds were determined on the basis of NMR analysis (1H, 13C, COSY and HMBC) as well as by mass spectrometry using ESI (Electron Spray Ionisation) as source.

KW - salvia officinalis

KW - endophytic fungi

KW - chaetomium

KW - secondary metabolites

KW - cochliodinol

KW - spectroscopy

KW - cytotoxicity

KW - morocco

UR - http://www.bib.fsagx.ac.be/base/eng/

UR - http://www.bib.fsagx.ac.be/base/text/v13n2/229.pdf

M3 - Article

VL - 13

SP - 229

EP - 234

JO - Biotechnology, Agronomy, Society and Environment (BASE)

JF - Biotechnology, Agronomy, Society and Environment (BASE)

SN - 1370-6233

IS - 2

ER -

Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this