Bioactive natural products from marine invertebrates and associated fungi

P Proksch, R Ebel, R A Edrada, V Wray, K Steube, Ruangelie Edrada-Ebel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Marine natural products with their unique structural features and pronounced biological activities continue to provide lead structures in the search for new drugs from nature. Invertebrates such as sponges, tunicates, mollusks and others that are either sessile or slow moving and mostly lack morphological defense structures have so far provided the largest number of marine-derived secondary constituents including some of the most interesting drug candidates. This review highlights recent research findings of our group related to natural products from marine invertebrates. Areas that are covered include ecological functions of secondary constituents from sponges against predatory fish, the search for new pharmacologically active constituents from sponges and tunicates, and sponge-associated fungi as an evolving source for new bioactive natural products.

Original languageEnglish
Pages (from-to)117-142
Number of pages26
JournalProgress in Molecular and Subcellular Biology
Volume37
DOIs
Publication statusPublished - 2003

Keywords

  • alkaloids
  • biodiversity
  • biological products
  • biotechnology
  • fungal Proteins
  • fungi
  • marine biology
  • oxazoles
  • porifera
  • staurosporine
  • urochordata

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