Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia

Ru Angelie Edrada, Peter Proksch, Victor Wray, Ruprecht Christ, Ludger Witte, Rob W M Van Soest

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). Compound 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (EC 50 of 35 ppm and LC 50 of 521 ppm) when incorporated into artificial diet. Compounds 1 and 3 were only weakly active toward S. littoralis, while compound 4 was found to be inactive. All four isolated compounds were active against the Gram-positive bacteria Bacillus subtilis and Staphyloccoccus aureus. Compound 4 was also active against the fungus Cladosporium cucumerinum.

Original languageEnglish
Pages (from-to)973-976
Number of pages4
JournalJournal of Natural Products
Volume59
Issue number10
DOIs
Publication statusPublished - 1 Oct 1996

Keywords

  • Philippine marine sponges
  • Xestospongia
  • isoquinoline quinones

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