Abstract
An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). Compound 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (EC 50 of 35 ppm and LC 50 of 521 ppm) when incorporated into artificial diet. Compounds 1 and 3 were only weakly active toward S. littoralis, while compound 4 was found to be inactive. All four isolated compounds were active against the Gram-positive bacteria Bacillus subtilis and Staphyloccoccus aureus. Compound 4 was also active against the fungus Cladosporium cucumerinum.
Original language | English |
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Pages (from-to) | 973-976 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 59 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 1996 |
Keywords
- Philippine marine sponges
- Xestospongia
- isoquinoline quinones