Bioactive constituents from bergia suffruticosa

A.A. Elegami, A.I. Gray, R.D. Waigh, H.E. Khalid

Research output: Contribution to journalArticle

Abstract

In vitro antibacterial investigation of the various extracts of Bergia suffruticosa leaf belonging to the family Elatinaceae: a plant used in Sudanese folk medicine to treat skin wounds [1] was evaluated against 72 strains of standard and clinical isolates of Gram positive and Gram negative bacteria. Six known compounds were isolated from methanolic extract, which was the most active fraction. The isolated compounds were Gallic acid methyl ester; Daucosterol; 1,2,3,6-Tetra-O-galloyl -β-glucose; 1,2,3,4,6-Penta-O-galloyl-β-glucose; Kaemferol-3-O-rhamnoside and Quercetin-3-O-rhamnoside. Their identification were based on their spectroscopic data (UV, IR, 1H & 13CNMR and MS). Gallic acid methyl ester was found to have MIC 25µg/ml against Staphylococcus aureus and Escherichia coli, whereas 1,2,3,6-Tetra-O-galloyl -β-glucose and 1,2,3,4,6-Penta-O-galloyl-β-glucose were found to be 50µg/ml against S. aureus and 100µg/ml against E. coli, the results suggested that the antibacterial effect of these two compounds is due to the presence of galloyl group. The MIC of other three compounds displayed no antibacterial activity against both organisms at 200µg/ml. Ampicillin and Gentamicin were used as reference antibacterial activity. In an early study, conducted the antibacterial activity of B. suffruticosa whole plant reported that, its methanolic extract showed significant inhibition of the four tested micro-organisms [2]. There is no phytochemical report encountered on the plant species undertaken in this study. This result justifies the traditional therapeutic use of the plant.
LanguageEnglish
Pages963-963
Number of pages0
JournalPlanta Medica
Volume75
Issue number9
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Escherichia coli
Glucose
Phytochemicals
Ampicillin
Gentamicins
Medicine
Staphylococcus aureus
Bacteria
Skin
Traditional Medicine
Therapeutic Uses
Gram-Negative Bacteria
methyl gallate
beta-penta-O-galloyl-glucose
Wounds and Injuries
lyoniside
quercitrin

Keywords

  • bergia suffruticosa leaf
  • folk medicine
  • skin wounds
  • antibacterial investigation

Cite this

Elegami, A. A., Gray, A. I., Waigh, R. D., & Khalid, H. E. (2009). Bioactive constituents from bergia suffruticosa. Planta Medica, 75(9), 963-963. https://doi.org/10.1055/s-0029-1234552
Elegami, A.A. ; Gray, A.I. ; Waigh, R.D. ; Khalid, H.E. / Bioactive constituents from bergia suffruticosa. In: Planta Medica. 2009 ; Vol. 75, No. 9. pp. 963-963.
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Elegami, AA, Gray, AI, Waigh, RD & Khalid, HE 2009, 'Bioactive constituents from bergia suffruticosa' Planta Medica, vol. 75, no. 9, pp. 963-963. https://doi.org/10.1055/s-0029-1234552

Bioactive constituents from bergia suffruticosa. / Elegami, A.A.; Gray, A.I.; Waigh, R.D.; Khalid, H.E.

In: Planta Medica, Vol. 75, No. 9, 07.2009, p. 963-963.

Research output: Contribution to journalArticle

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Elegami AA, Gray AI, Waigh RD, Khalid HE. Bioactive constituents from bergia suffruticosa. Planta Medica. 2009 Jul;75(9):963-963. https://doi.org/10.1055/s-0029-1234552