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Abstract
The present disclosure relates to cell penetrating anti-DNA binding proteins. Compositions comprising these binding proteins may be may be useful for delivering agents to cells and treating diseases such as cancer.
| Original language | English |
|---|---|
| Patent number | WO2019018426A1 |
| IPC | C07K 16/44,C07K 16/18 |
| Priority date | 17/07/17 |
| Filing date | 17/07/18 |
| Publication status | Published - 24 Jan 2019 |
Keywords
- antibody
- cell penetrating
- antineoplastic agents
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ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody
Rattray, Z., Deng, G., Zhang, S., Shirali, A., May, C. K., Chen, X., Cuffari, B. J., Liu, J., Zou, P., Rattray, N. J. W., Johnson, C. H., Dubljevic, V., Campbell, J. A., Huttner, A., Baehring, J. M., Zhou, J. & Hansen, J. E., 22 Jul 2021, In: JCI Insight. 6, 14, 39 p., e145875.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)54 Downloads (Pure) -
An ENT2-dependent, cell-penetrating, and DNA-damaging lupus autoantibody crosses the blood-brain barrier to target brain tumors
Rattray, Z., Deng, G., Zhang, S., Shirali, A., May, C., Liu, J., Zou, P., Cuffari, B., Rattray, N., Johnson, C., Dubljevic, V., Campbell, J., Huttner, A., Baehring, J., Zhou, J. & Hansen, J., 4 Aug 2020, In: Neuro-Oncology Advances. 2, Supplement 2, p. ii13-ii13 1 p.Research output: Contribution to journal › Conference abstract › peer-review
Open Access -
A DNA-damaging lupus autoantibody synergizes with PARP inhibitors against DNA repair-deficient tumor cells
Rattray, Z., Patel, J. M., Noble, P. W., Dubljevic, V., Greenwood, D. L., Campbell, J. A. & Hansen, J. E., 30 Jul 2018, In: Cancer Research. 78, 13 (Supp), p. 2773 1 p.Research output: Contribution to journal › Conference abstract › peer-review