Bicyclic 6-6 systems: Pteridines

C. Suckling, C. Gibson, J. Huggan

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

This chapter outlines research on pteridines in all its published aspects covering the literature from 1996 to mid-2006. Following previous editions of this work, the review outlines the historical background to pteridine research and basic structural aspects. Physical properties, notably redox properties, and the growing number of crystal structures of pteridine metal complexes are covered. The reactivity of pteridines described principally relates to substitution at nitrogen (especially forming glycosides), nucleophilic displacements of leaving groups at carbon, organometallic coupling of halides and triflates, and side-chain oxidation and condensation. Recent developments of pteridine synthesis highlight refinements of well-established methods based either upon pyrimidines or pyrazines as precursors such that selectivity and scope can be improved. Compounds and features of special interest that have developed in the decade covered include metal complexes, nucleic acid analogues, biosynthetic pathways and mechanisms, new natural products (glycosides and alkaloids), and, in particular, medicinal chemistry (both anti-infective and anticancer compounds).
Original languageEnglish
Title of host publicationComprehensive Heterocyclic Chemistry III
EditorsAlan R. Katritzky, Eric F.V. Scriven, Christopher A. Ramsden, Richard J.K. Taylor
PublisherElsevier Ltd.
Chapter18
Pages915-975
Number of pages61
Volume10
ISBN (Print)9780080449920
DOIs
Publication statusPublished - 4 Apr 2008

Keywords

  • pteridines
  • heterocyclic chemistry
  • reference work

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