Benefits of supervised group exercise programme for women being treated for early stage breast cancer

pragmatic randomised controlled trial

Nanette Mutrie, Anna M. Campbell, Fiona Whyte, Alex McConnachie, Carol Emslie, Laura Lee, Nora Keaney, Andrew Walker, Diana Ritchie

Research output: Contribution to journalArticle

263 Citations (Scopus)
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Abstract

Objectives: To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design: Pragmatic randomised controlled prospective open trial. Setting: Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants: 203 women entered the study; 177 completed the six month follow-up. Interventions: Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures: Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results: Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion: Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services.
Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalBritish Medical Journal
Volume334
Issue number7592
DOIs
Publication statusPublished - 10 Mar 2007

Fingerprint

Randomized Controlled Trials
Exercise
Breast Neoplasms
Quality of Life
Psychology
Neoplasms
National Health Programs
Scotland
Therapeutics
Administrative Personnel
Body Mass Index
Rehabilitation
Outcome Assessment (Health Care)
Confidence Intervals
Depression
Equipment and Supplies

Keywords

  • breast cancer
  • exercise
  • sports medicine

Cite this

Mutrie, Nanette ; Campbell, Anna M. ; Whyte, Fiona ; McConnachie, Alex ; Emslie, Carol ; Lee, Laura ; Keaney, Nora ; Walker, Andrew ; Ritchie, Diana. / Benefits of supervised group exercise programme for women being treated for early stage breast cancer : pragmatic randomised controlled trial. In: British Medical Journal. 2007 ; Vol. 334, No. 7592. pp. 517-523.
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Mutrie, N, Campbell, AM, Whyte, F, McConnachie, A, Emslie, C, Lee, L, Keaney, N, Walker, A & Ritchie, D 2007, 'Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial', British Medical Journal, vol. 334, no. 7592, pp. 517-523. https://doi.org/10.1136/bmj.39094.648553.AE

Benefits of supervised group exercise programme for women being treated for early stage breast cancer : pragmatic randomised controlled trial. / Mutrie, Nanette; Campbell, Anna M.; Whyte, Fiona; McConnachie, Alex; Emslie, Carol; Lee, Laura; Keaney, Nora; Walker, Andrew; Ritchie, Diana.

In: British Medical Journal, Vol. 334, No. 7592, 10.03.2007, p. 517-523.

Research output: Contribution to journalArticle

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T1 - Benefits of supervised group exercise programme for women being treated for early stage breast cancer

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AU - Mutrie, Nanette

AU - Campbell, Anna M.

AU - Whyte, Fiona

AU - McConnachie, Alex

AU - Emslie, Carol

AU - Lee, Laura

AU - Keaney, Nora

AU - Walker, Andrew

AU - Ritchie, Diana

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N2 - Objectives: To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design: Pragmatic randomised controlled prospective open trial. Setting: Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants: 203 women entered the study; 177 completed the six month follow-up. Interventions: Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures: Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results: Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion: Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services.

AB - Objectives: To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design: Pragmatic randomised controlled prospective open trial. Setting: Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants: 203 women entered the study; 177 completed the six month follow-up. Interventions: Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures: Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results: Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion: Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services.

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