Behavioral and pharmacological specificity of the feeding elicited by cholinergic stimulation of the substantia nigra in the rat

Philip Winn, Angela Farrell, Adrian Maconick, Trevor W. Robbins

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Microinjections of the cholinergic agonist carbachol into anterior substantia nigra dose dependently increased food intake in satiated rats. This resulted from a prolongation of the duration of eating. In the absence of food, those doses of carbachol that stimulated food intake (.1 and .5 μg) had no effect on any other response examined, including gnawing, drinking, locomotion, grooming, sniffing, and rearing. The effect of carbachol depended on the degree of prior food deprivation, but supra-additive effects of carbachol and deprivation were not observed. These results are contrasted with those of previous studies demonstrating the nonspecific behavioral effects of electrical stimulation of the brain and of studies showing that carbachol has radically different behavioral effects at other central nervous system sites. Microinjection of an acetylcholine/eserine sulfate mixture also significantly increased food intake. This response was abolished by prior microinjection of the muscarinic receptor antagonist atropine into the substantia nigra, a result that provides evidence for pharmacological specificity of the behavioral effects. These data provide further evidence for the hypothesis that a functional cholinergic system is present within substantia nigra.
LanguageEnglish
Pages794-809
Number of pages16
JournalBehavioral Neuroscience
Volume97
Issue number5
DOIs
Publication statusPublished - 31 Oct 1983

Fingerprint

Carbachol
Substantia Nigra
Cholinergic Agents
Pharmacology
Microinjections
Eating
Food Deprivation
Cholinergic Agonists
Grooming
Physostigmine
Muscarinic Antagonists
Deep Brain Stimulation
Muscarinic Receptors
Locomotion
Atropine
Sulfates
Drinking
Acetylcholine
Central Nervous System
Food

Keywords

  • substantia nigra
  • feeding
  • cholinergic stimulation
  • acetylcholine
  • eserine

Cite this

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Behavioral and pharmacological specificity of the feeding elicited by cholinergic stimulation of the substantia nigra in the rat. / Winn, Philip; Farrell, Angela; Maconick, Adrian; Robbins, Trevor W.

In: Behavioral Neuroscience, Vol. 97, No. 5, 31.10.1983, p. 794-809.

Research output: Contribution to journalArticle

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