Behavioral and electrophysiological correlates of memory binding deficits in patients at different risk levels for Alzheimer's Disease

Marcos Pietto, Mario A. Parra, Natalia Trujillo, Facundo Flores, Adolfo M. García, Julian Bustin, Pablo Richly, Facundo Manes, Francisco Lopera, Agustín Ibáñez, Sandra Baez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Deficits in visual short-term memory (VSTM) binding have been proposed as an early and specific marker for Alzheimer's disease (AD). However, no studies have explored the neural correlates of this domain in clinical categories involving prodromal stages with different risk levels of conversion to AD. We assessed underlying electrophysiological modulations in patients with mild cognitive impairment (MCI), patients in the MCI stages of familial AD carrying the mutation E280A of the presenilin-1 gene (MCI-FAD), and healthy controls. Moreover, we compared the behavioral performance and neural correlates of both patient groups. Participants completed a change-detection VSTM task assessing recognition of changes between shapes or shape-color bindings, presented in two consecutive arrays (i.e., study and test) while event related potentials (ERPs) were recorded. Changes always occurred in the test array and consisted of new features replacing studied features (shape-only) or features swapping across items (shape-color binding). Both MCI and MCI-FAD patients performed worse than controls in the shape-color binding condition. Early electrophysiological activity (100-250 ms) was significantly reduced in both clinical groups, particularly over fronto-central and parieto-occipital regions. However, shape-color binding performance and their reduced neural correlates were similar between MCI and MCI-FAD. Our results support the validity of the VSTM binding test and their neural correlates in the early detection of AD and highlight the importance of studies comparing samples at different risk for AD conversion. The combined analysis of behavioral and ERP data gleaned with the VSTM binding task can offer a valuable memory biomarker for AD.

LanguageEnglish
Pages1325-1340
Number of pages16
JournalJournal of Alzheimer's Disease
Volume53
Issue number4
DOIs
Publication statusPublished - 30 Jun 2016

Fingerprint

Memory Disorders
Alzheimer Disease
Short-Term Memory
Flavin-Adenine Dinucleotide
Color
Evoked Potentials
Presenilin-1
Prodromal Symptoms
Occipital Lobe
Cognitive Dysfunction
Reproducibility of Results
Early Diagnosis
Biomarkers
Mutation
Genes

Keywords

  • Alzheimer Disease/genetics
  • brain/physiopathology
  • cognitive dysfunction/genetics
  • electroencephalography
  • Evoked Potentials
  • heterozygote
  • memory disorders/genetics
  • neuropsychological tests
  • pattern recognition, visual/physiology
  • Presenilin-1/genetics
  • prodromal symptoms

Cite this

Pietto, Marcos ; Parra, Mario A. ; Trujillo, Natalia ; Flores, Facundo ; García, Adolfo M. ; Bustin, Julian ; Richly, Pablo ; Manes, Facundo ; Lopera, Francisco ; Ibáñez, Agustín ; Baez, Sandra. / Behavioral and electrophysiological correlates of memory binding deficits in patients at different risk levels for Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2016 ; Vol. 53, No. 4. pp. 1325-1340.
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abstract = "Deficits in visual short-term memory (VSTM) binding have been proposed as an early and specific marker for Alzheimer's disease (AD). However, no studies have explored the neural correlates of this domain in clinical categories involving prodromal stages with different risk levels of conversion to AD. We assessed underlying electrophysiological modulations in patients with mild cognitive impairment (MCI), patients in the MCI stages of familial AD carrying the mutation E280A of the presenilin-1 gene (MCI-FAD), and healthy controls. Moreover, we compared the behavioral performance and neural correlates of both patient groups. Participants completed a change-detection VSTM task assessing recognition of changes between shapes or shape-color bindings, presented in two consecutive arrays (i.e., study and test) while event related potentials (ERPs) were recorded. Changes always occurred in the test array and consisted of new features replacing studied features (shape-only) or features swapping across items (shape-color binding). Both MCI and MCI-FAD patients performed worse than controls in the shape-color binding condition. Early electrophysiological activity (100-250 ms) was significantly reduced in both clinical groups, particularly over fronto-central and parieto-occipital regions. However, shape-color binding performance and their reduced neural correlates were similar between MCI and MCI-FAD. Our results support the validity of the VSTM binding test and their neural correlates in the early detection of AD and highlight the importance of studies comparing samples at different risk for AD conversion. The combined analysis of behavioral and ERP data gleaned with the VSTM binding task can offer a valuable memory biomarker for AD.",
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Pietto, M, Parra, MA, Trujillo, N, Flores, F, García, AM, Bustin, J, Richly, P, Manes, F, Lopera, F, Ibáñez, A & Baez, S 2016, 'Behavioral and electrophysiological correlates of memory binding deficits in patients at different risk levels for Alzheimer's Disease' Journal of Alzheimer's Disease, vol. 53, no. 4, pp. 1325-1340. https://doi.org/10.3233/JAD-160056

Behavioral and electrophysiological correlates of memory binding deficits in patients at different risk levels for Alzheimer's Disease. / Pietto, Marcos; Parra, Mario A.; Trujillo, Natalia; Flores, Facundo; García, Adolfo M.; Bustin, Julian; Richly, Pablo; Manes, Facundo; Lopera, Francisco; Ibáñez, Agustín; Baez, Sandra.

In: Journal of Alzheimer's Disease, Vol. 53, No. 4, 30.06.2016, p. 1325-1340.

Research output: Contribution to journalArticle

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T1 - Behavioral and electrophysiological correlates of memory binding deficits in patients at different risk levels for Alzheimer's Disease

AU - Pietto, Marcos

AU - Parra, Mario A.

AU - Trujillo, Natalia

AU - Flores, Facundo

AU - García, Adolfo M.

AU - Bustin, Julian

AU - Richly, Pablo

AU - Manes, Facundo

AU - Lopera, Francisco

AU - Ibáñez, Agustín

AU - Baez, Sandra

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AB - Deficits in visual short-term memory (VSTM) binding have been proposed as an early and specific marker for Alzheimer's disease (AD). However, no studies have explored the neural correlates of this domain in clinical categories involving prodromal stages with different risk levels of conversion to AD. We assessed underlying electrophysiological modulations in patients with mild cognitive impairment (MCI), patients in the MCI stages of familial AD carrying the mutation E280A of the presenilin-1 gene (MCI-FAD), and healthy controls. Moreover, we compared the behavioral performance and neural correlates of both patient groups. Participants completed a change-detection VSTM task assessing recognition of changes between shapes or shape-color bindings, presented in two consecutive arrays (i.e., study and test) while event related potentials (ERPs) were recorded. Changes always occurred in the test array and consisted of new features replacing studied features (shape-only) or features swapping across items (shape-color binding). Both MCI and MCI-FAD patients performed worse than controls in the shape-color binding condition. Early electrophysiological activity (100-250 ms) was significantly reduced in both clinical groups, particularly over fronto-central and parieto-occipital regions. However, shape-color binding performance and their reduced neural correlates were similar between MCI and MCI-FAD. Our results support the validity of the VSTM binding test and their neural correlates in the early detection of AD and highlight the importance of studies comparing samples at different risk for AD conversion. The combined analysis of behavioral and ERP data gleaned with the VSTM binding task can offer a valuable memory biomarker for AD.

KW - Alzheimer Disease/genetics

KW - brain/physiopathology

KW - cognitive dysfunction/genetics

KW - electroencephalography

KW - Evoked Potentials

KW - heterozygote

KW - memory disorders/genetics

KW - neuropsychological tests

KW - pattern recognition, visual/physiology

KW - Presenilin-1/genetics

KW - prodromal symptoms

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DO - 10.3233/JAD-160056

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EP - 1340

JO - Journal of Alzheimer's Disease

T2 - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

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ER -