BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation

Research output: Contribution to conferencePoster

Abstract

Non-invasive anodal trans-spinal direct current stimulation (tsDCS) can modulate central nervous system activity (1-5) with effects lasting for at least one hour post stimulation. In healthy subjects we observed tsDCS to alter the performance of repeated maximal effort explosive countermovement vertical jumps through effects on motor fatigue mechanisms and coordination (6). However, there is significant variability between subjects. Brain-derived neurotrophic factor (BDNF) is a key mediator of activity-based neuroplasticity. Carriers of the BDNF Val66Met single nucleotide polymorphism (Met SNP; rs6265) secrete less BDNF (7) and have altered neuroplastic responses to tsDCS (8) compared to normal Val66Val carriers. Accordingly, we are investigating if any association can be identified between BDNF genotype and changes in repeated jump performance following sham and active anodal tsDCS.

Conference

ConferenceInternational Neuromodulation Society 13th World Congress
CountryUnited Kingdom
CityEdinburgh
Period27/05/171/06/17
Internet address

Fingerprint

Polymorphism
Brain
Fatigue of materials
Neurology
Nucleotides
Nerve Growth Factors

Keywords

  • trans-spinal direct current stimulation
  • tsDCS
  • brain-derived neurotrophic factor
  • BDNF

Cite this

Berry, H. R., Tate, R., Campbell, C., & Conway, B. (2017). BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation. Poster session presented at International Neuromodulation Society 13th World Congress, Edinburgh, United Kingdom.
Berry, Helen R. ; Tate, Rothwelle ; Campbell, Conor ; Conway, Bernard. / BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation. Poster session presented at International Neuromodulation Society 13th World Congress, Edinburgh, United Kingdom.
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abstract = "Non-invasive anodal trans-spinal direct current stimulation (tsDCS) can modulate central nervous system activity (1-5) with effects lasting for at least one hour post stimulation. In healthy subjects we observed tsDCS to alter the performance of repeated maximal effort explosive countermovement vertical jumps through effects on motor fatigue mechanisms and coordination (6). However, there is significant variability between subjects. Brain-derived neurotrophic factor (BDNF) is a key mediator of activity-based neuroplasticity. Carriers of the BDNF Val66Met single nucleotide polymorphism (Met SNP; rs6265) secrete less BDNF (7) and have altered neuroplastic responses to tsDCS (8) compared to normal Val66Val carriers. Accordingly, we are investigating if any association can be identified between BDNF genotype and changes in repeated jump performance following sham and active anodal tsDCS.",
keywords = "trans-spinal direct current stimulation , tsDCS, brain-derived neurotrophic factor, BDNF",
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Berry, HR, Tate, R, Campbell, C & Conway, B 2017, 'BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation' International Neuromodulation Society 13th World Congress, Edinburgh, United Kingdom, 27/05/17 - 1/06/17, .

BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation. / Berry, Helen R.; Tate, Rothwelle; Campbell, Conor; Conway, Bernard.

2017. Poster session presented at International Neuromodulation Society 13th World Congress, Edinburgh, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation

AU - Berry, Helen R.

AU - Tate, Rothwelle

AU - Campbell, Conor

AU - Conway, Bernard

PY - 2017/5/31

Y1 - 2017/5/31

N2 - Non-invasive anodal trans-spinal direct current stimulation (tsDCS) can modulate central nervous system activity (1-5) with effects lasting for at least one hour post stimulation. In healthy subjects we observed tsDCS to alter the performance of repeated maximal effort explosive countermovement vertical jumps through effects on motor fatigue mechanisms and coordination (6). However, there is significant variability between subjects. Brain-derived neurotrophic factor (BDNF) is a key mediator of activity-based neuroplasticity. Carriers of the BDNF Val66Met single nucleotide polymorphism (Met SNP; rs6265) secrete less BDNF (7) and have altered neuroplastic responses to tsDCS (8) compared to normal Val66Val carriers. Accordingly, we are investigating if any association can be identified between BDNF genotype and changes in repeated jump performance following sham and active anodal tsDCS.

AB - Non-invasive anodal trans-spinal direct current stimulation (tsDCS) can modulate central nervous system activity (1-5) with effects lasting for at least one hour post stimulation. In healthy subjects we observed tsDCS to alter the performance of repeated maximal effort explosive countermovement vertical jumps through effects on motor fatigue mechanisms and coordination (6). However, there is significant variability between subjects. Brain-derived neurotrophic factor (BDNF) is a key mediator of activity-based neuroplasticity. Carriers of the BDNF Val66Met single nucleotide polymorphism (Met SNP; rs6265) secrete less BDNF (7) and have altered neuroplastic responses to tsDCS (8) compared to normal Val66Val carriers. Accordingly, we are investigating if any association can be identified between BDNF genotype and changes in repeated jump performance following sham and active anodal tsDCS.

KW - trans-spinal direct current stimulation

KW - tsDCS

KW - brain-derived neurotrophic factor

KW - BDNF

M3 - Poster

ER -

Berry HR, Tate R, Campbell C, Conway B. BDNF Val66Met polymorphism attenuates explosive jump fatigue differentially after trans-spinal anodal direct current stimulation. 2017. Poster session presented at International Neuromodulation Society 13th World Congress, Edinburgh, United Kingdom.