Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus

Wendy L. Inglis, Jay S. Dunbar, Philip Winn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and Avertin (tribromoethanol/tert-amylalcohol dissolved in ethanol, saline and phosphate buffer), on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABAA receptor.

LanguageEnglish
Pages78-82
Number of pages5
JournalNeuroscience Letters
Volume156
Issue number1-2
DOIs
Publication statusPublished - 25 Jun 1993

Fingerprint

Pedunculopontine Tegmental Nucleus
Quinolinic Acid
Anesthesia
Neurons
Barbiturates
Cholinergic Neurons
Neurotoxins
Glutamate Receptors
Pentobarbital
GABA-A Receptors
Anesthetics
Buffers
Ethanol
Sodium
Phosphates
barbituric acid
tribromoethanol

Keywords

  • anaesthesia
  • avertin
  • barbiturate
  • diaphorase
  • ibotenate
  • pedunculopontine tegmental nucleus
  • quinolinate
  • rat
  • 4 aminobutyric acid a receptor
  • anesthetic agent
  • excitotoxin
  • ibotenic acid
  • quinolinic acid
  • neurotoxicity

Cite this

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Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus. / Inglis, Wendy L.; Dunbar, Jay S.; Winn, Philip.

In: Neuroscience Letters, Vol. 156, No. 1-2, 25.06.1993, p. 78-82.

Research output: Contribution to journalArticle

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