Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

James R. Hands, Konrad M. Dorling, Peter Abel, Katherine M. Ashton, Andrew Brodbelt, Charles Davis, Timothy Dawson, Michael D. Jenkinson, Robert W. Lea, Carol Walker, Matthew J. Baker

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.

LanguageEnglish
Pages189-199
Number of pages11
JournalJournal of Biophotonics
Volume7
Issue number3-4
Early online date7 Jan 2014
DOIs
Publication statusPublished - 1 Apr 2014

Fingerprint

Fourier Analysis
Brain Neoplasms
Glioma
serums
brain
discrimination
Tumors
grade
Brain
Fourier transforms
tumors
Spectroscopy
Infrared radiation
Planning
Monitoring
mortality
Serum
reagents
planning
Costs

Keywords

  • ATR-FTIR
  • cancer
  • filtrate
  • glioma
  • infrared
  • rapid
  • serum
  • spectroscopy

Cite this

Hands, James R. ; Dorling, Konrad M. ; Abel, Peter ; Ashton, Katherine M. ; Brodbelt, Andrew ; Davis, Charles ; Dawson, Timothy ; Jenkinson, Michael D. ; Lea, Robert W. ; Walker, Carol ; Baker, Matthew J. / Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples. In: Journal of Biophotonics. 2014 ; Vol. 7, No. 3-4. pp. 189-199.
@article{f621d52b793f405eb9eb2b955b759510,
title = "Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples",
abstract = "Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53{\%} respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.",
keywords = "ATR-FTIR, cancer, filtrate, glioma, infrared, rapid, serum, spectroscopy",
author = "Hands, {James R.} and Dorling, {Konrad M.} and Peter Abel and Ashton, {Katherine M.} and Andrew Brodbelt and Charles Davis and Timothy Dawson and Jenkinson, {Michael D.} and Lea, {Robert W.} and Carol Walker and Baker, {Matthew J.}",
year = "2014",
month = "4",
day = "1",
doi = "10.1002/jbio.201300149",
language = "English",
volume = "7",
pages = "189--199",
journal = "Journal of Biophotonics",
issn = "1864-063X",
number = "3-4",

}

Hands, JR, Dorling, KM, Abel, P, Ashton, KM, Brodbelt, A, Davis, C, Dawson, T, Jenkinson, MD, Lea, RW, Walker, C & Baker, MJ 2014, 'Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples' Journal of Biophotonics, vol. 7, no. 3-4, pp. 189-199. https://doi.org/10.1002/jbio.201300149

Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples. / Hands, James R.; Dorling, Konrad M.; Abel, Peter; Ashton, Katherine M.; Brodbelt, Andrew; Davis, Charles; Dawson, Timothy; Jenkinson, Michael D.; Lea, Robert W.; Walker, Carol; Baker, Matthew J.

In: Journal of Biophotonics, Vol. 7, No. 3-4, 01.04.2014, p. 189-199.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

AU - Hands, James R.

AU - Dorling, Konrad M.

AU - Abel, Peter

AU - Ashton, Katherine M.

AU - Brodbelt, Andrew

AU - Davis, Charles

AU - Dawson, Timothy

AU - Jenkinson, Michael D.

AU - Lea, Robert W.

AU - Walker, Carol

AU - Baker, Matthew J.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.

AB - Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.

KW - ATR-FTIR

KW - cancer

KW - filtrate

KW - glioma

KW - infrared

KW - rapid

KW - serum

KW - spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84897960854&partnerID=8YFLogxK

U2 - 10.1002/jbio.201300149

DO - 10.1002/jbio.201300149

M3 - Article

VL - 7

SP - 189

EP - 199

JO - Journal of Biophotonics

T2 - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 3-4

ER -