Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

James R. Hands; Konrad M. Dorling; Peter Abel; Katherine M. Ashton; Andrew Brodbelt; Charles Davis; Timothy Dawson; Michael D. Jenkinson; Robert W. Lea; Carol Walker; Matthew J. Baker

doi:10.1002/jbio.201300149

Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

James R. Hands, Konrad M. Dorling, Peter Abel, Katherine M. Ashton, Andrew Brodbelt, Charles Davis, Timothy Dawson, Michael D. Jenkinson, Robert W. Lea, Carol Walker, Matthew J. Baker^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Journal of Biophotonics
Volume	7
Issue number	3-4
Early online date	7 Jan 2014
DOIs	https://doi.org/10.1002/jbio.201300149
Publication status	Published - 1 Apr 2014

Keywords

ATR-FTIR
cancer
filtrate
glioma
infrared
rapid
serum
spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jbio.201300149

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Hands, J. R., Dorling, K. M., Abel, P., Ashton, K. M., Brodbelt, A., Davis, C., Dawson, T., Jenkinson, M. D., Lea, R. W., Walker, C., & Baker, M. J. (2014). Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples. Journal of Biophotonics, 7(3-4), 189-199. https://doi.org/10.1002/jbio.201300149

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AU - Hands, James R.

AU - Dorling, Konrad M.

AU - Abel, Peter

AU - Ashton, Katherine M.

AU - Brodbelt, Andrew

AU - Davis, Charles

AU - Dawson, Timothy

AU - Jenkinson, Michael D.

AU - Lea, Robert W.

AU - Walker, Carol

AU - Baker, Matthew J.

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AB - Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.

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KW - cancer

KW - filtrate

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KW - rapid

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Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

Abstract

Keywords

UN SDGs

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