Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group

Niall A Anderson, Brendan J Fallon, Elena Valverde, Simon J F MacDonald, John M Pritchard, Colin Suckling, Allan Watson

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Application of the Miyaura–Hayashi rhodium-catalysed addition of aryl boronic acids to acyclic unsaturated esters featuring basic centres to yield γ-amino butyric acids incorporating a substituted β-phenyl group is described. Unoptimised isolated yields and enantiomeric excesses vary from moderate to excellent, and the
method tolerates a variety of substitution patterns and a range of functionality.
Original languageEnglish
Pages (from-to)2817-2821
Number of pages5
JournalSynlett
Volume23
Issue number19
DOIs
Publication statusPublished - Dec 2012

Keywords

  • rhodium
  • asymmetric
  • 1,4-addition
  • drugs
  • γ-aminobutyric acid
  • synthesis

Fingerprint Dive into the research topics of 'Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group'. Together they form a unique fingerprint.

Cite this