Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group

Niall A Anderson, Brendan J Fallon, Elena Valverde, Simon J F MacDonald, John M Pritchard, Colin Suckling, Allan Watson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Application of the Miyaura–Hayashi rhodium-catalysed addition of aryl boronic acids to acyclic unsaturated esters featuring basic centres to yield γ-amino butyric acids incorporating a substituted β-phenyl group is described. Unoptimised isolated yields and enantiomeric excesses vary from moderate to excellent, and the
method tolerates a variety of substitution patterns and a range of functionality.
Original languageEnglish
Pages (from-to)2817-2821
Number of pages5
JournalSynlett
Volume23
Issue number19
DOIs
Publication statusPublished - Dec 2012

    Fingerprint

Keywords

  • rhodium
  • asymmetric
  • 1,4-addition
  • drugs
  • γ-aminobutyric acid
  • synthesis

Cite this

Anderson, N. A., Fallon, B. J., Valverde, E., MacDonald, S. J. F., Pritchard, J. M., Suckling, C., & Watson, A. (2012). Asymmetric rhodium-catalysed addition of arylboronic acids to acyclic unsaturated esters containing a basic γ-amino group. Synlett, 23(19), 2817-2821. https://doi.org/10.1055/s-0032-1317512