Associative Memory Models of Hippocampal Areas CA1 and CA3

Bruce P. Graham, Vassilis Cutsuridis, Russell Hunter

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The hippocampal regions CA3 and CA1 have long been proposed to be auto and heteroassociative memories, respectively (Marr, 1971; McNaughton and Morris, 1987; Treves and Rolls, 1994), for the storage of declarative information. An autoassociative memory is formed when a set of neurons are recurrently connected by modifiable synapses, whereas a heteroassociative memory is formed through modifiable connections from an input layer of neurons to an output layer. Associative memory storage simply requires a Hebbian strengthening of connections between neurons that are coactive (Amit, 1989; Hopfield, 1982; Willshaw et al., 1969). Recall proceeds from a cue activity pattern across neurons that is a partial or noisy version of a previously stored pattern. A suitable firing threshold on each neuron that receives input from already active neurons ensures that neural activity evolves towards the stored pattern. This may happen with only one or two updates of each neuron’s activity.
LanguageEnglish
Title of host publicationHippocampal Microcircuits
Subtitle of host publicationA Computational Modeler's Resource Book
EditorsBruce Graham, Vassilis Cutsuridis, Stuart Cobb, Imre Vida
Place of PublicationNew York
PublisherSpringer
Pages459-494
Number of pages36
Volume5
ISBN (Electronic)9781441909961
ISBN (Print)9781441909954
DOIs
Publication statusPublished - 2010

Publication series

NameComputational Neuroscience
PublisherSpringer
Volume5

Fingerprint

Neurons
Data storage equipment
Hippocampal CA3 Region
Hippocampal CA1 Region
Information Storage and Retrieval
Synapses
Cues

Keywords

  • associative memory models
  • neurons
  • pyramidal cell
  • entorhinal cortex
  • spike train
  • inhibitory interneuron
  • Theta rhythm

Cite this

Graham, B. P., Cutsuridis, V., & Hunter, R. (2010). Associative Memory Models of Hippocampal Areas CA1 and CA3. In B. Graham, V. Cutsuridis, S. Cobb, & I. Vida (Eds.), Hippocampal Microcircuits: A Computational Modeler's Resource Book (Vol. 5, pp. 459-494). (Computational Neuroscience; Vol. 5). New York: Springer. https://doi.org/10.1007/978-1-4419-0996-1_16
Graham, Bruce P. ; Cutsuridis, Vassilis ; Hunter, Russell. / Associative Memory Models of Hippocampal Areas CA1 and CA3. Hippocampal Microcircuits: A Computational Modeler's Resource Book. editor / Bruce Graham ; Vassilis Cutsuridis ; Stuart Cobb ; Imre Vida. Vol. 5 New York : Springer, 2010. pp. 459-494 (Computational Neuroscience).
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Graham, BP, Cutsuridis, V & Hunter, R 2010, Associative Memory Models of Hippocampal Areas CA1 and CA3. in B Graham, V Cutsuridis, S Cobb & I Vida (eds), Hippocampal Microcircuits: A Computational Modeler's Resource Book. vol. 5, Computational Neuroscience, vol. 5, Springer, New York, pp. 459-494. https://doi.org/10.1007/978-1-4419-0996-1_16

Associative Memory Models of Hippocampal Areas CA1 and CA3. / Graham, Bruce P.; Cutsuridis, Vassilis; Hunter, Russell.

Hippocampal Microcircuits: A Computational Modeler's Resource Book. ed. / Bruce Graham; Vassilis Cutsuridis; Stuart Cobb; Imre Vida. Vol. 5 New York : Springer, 2010. p. 459-494 (Computational Neuroscience; Vol. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Graham BP, Cutsuridis V, Hunter R. Associative Memory Models of Hippocampal Areas CA1 and CA3. In Graham B, Cutsuridis V, Cobb S, Vida I, editors, Hippocampal Microcircuits: A Computational Modeler's Resource Book. Vol. 5. New York: Springer. 2010. p. 459-494. (Computational Neuroscience). https://doi.org/10.1007/978-1-4419-0996-1_16