Associations of biomechanical properties of the cornea with environmental and metabolic factors in an elderly population: the ALIENOR study

Cedric Schweitzer, Jean-Francois Korobelnik, Mathieu Boniol, Audrey Cougnard-Gregoire, Melanie Le Goff, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Jean-Francois Dartigues, Cecile Delcourt

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Abstract

PURPOSE: The purpose of this study was to assess the associations of biomechanical properties of the cornea with metabolic and environmental factors in an elderly population. METHODS: The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition, and Maladies OculaiRes) study is a population-based study. In 2009-2010, 624 subjects, aged 74 years or more, underwent an eye examination, including intraocular pressure (IOP), central corneal thickness (CCT), and biomechanical properties of the cornea measurements using the Ocular Response Analyzer. Socio-demographic, lifestyle, and medical history data were collected using standardized questionnaires. Mean lifetime ambient ultraviolet (UV) exposure was estimated using residential history and statistics of UV radiation at each location using the Eurosun UV database. RESULTS: Mean age was 82.2 ± 4.3 years. Mean corneal hysteresis (CH), corneal resistance factor (CRF), and CCT were 9.4 ± 1.9, 9.8 ± 1.9 mm Hg, and 551.6 ± 36.8 μm, respectively. In the multivariate analysis, CH and CRF values were significantly lower in subjects older than 80 years (-0.56; 95% confidence interval [CI]: -0.89;-0.24); P < 0.001 and -0.48; 95% CI: -0.75;-0.20; P < 0.001, respectively), in subjects having higher ambient UV exposure (-0.50; 95% CI: -0.88;-0.12; P < 0.01; and -0.46; 95% CI: -0.78;-0.13); P < 0.05, respectively), and in subjects with high plasma LDL cholesterol (CH: -0.46; 95% CI: -0.86;-0.03; P < 0.05; and CRF: -0.37; 95% CI: -0.72;-0.008; P < 0.05). Central corneal thickness was significantly higher in former smokers than in never smokers (+11.01; 95% CI: 0.48;21.55; P < 0.05) and was not significantly associated with age, ambient UV exposure, diabetes, or LDL cholesterol. CONCLUSIONS: Biomechanical properties of the cornea are modified by metabolic and lifetime environmental factors, especially UV exposure. The manner these factors may influence onset and progression of ocular diseases or IOP measurements need further investigation.
LanguageEnglish
Pages2003-2011
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

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Cornea
Confidence Intervals
R Factors
Population
Intraocular Pressure
LDL Cholesterol
Eye Diseases
Life Style
Multivariate Analysis
History
Demography
Databases
Radiation

Keywords

  • cornea
  • elderly population
  • antioxydants
  • lipides essentiels
  • nutrition

Cite this

Schweitzer, Cedric ; Korobelnik, Jean-Francois ; Boniol, Mathieu ; Cougnard-Gregoire, Audrey ; Le Goff, Melanie ; Malet, Florence ; Rougier, Marie-Benedicte ; Delyfer, Marie-Noelle ; Dartigues, Jean-Francois ; Delcourt, Cecile. / Associations of biomechanical properties of the cornea with environmental and metabolic factors in an elderly population : the ALIENOR study. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 4. pp. 2003-2011.
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abstract = "PURPOSE: The purpose of this study was to assess the associations of biomechanical properties of the cornea with metabolic and environmental factors in an elderly population. METHODS: The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition, and Maladies OculaiRes) study is a population-based study. In 2009-2010, 624 subjects, aged 74 years or more, underwent an eye examination, including intraocular pressure (IOP), central corneal thickness (CCT), and biomechanical properties of the cornea measurements using the Ocular Response Analyzer. Socio-demographic, lifestyle, and medical history data were collected using standardized questionnaires. Mean lifetime ambient ultraviolet (UV) exposure was estimated using residential history and statistics of UV radiation at each location using the Eurosun UV database. RESULTS: Mean age was 82.2 ± 4.3 years. Mean corneal hysteresis (CH), corneal resistance factor (CRF), and CCT were 9.4 ± 1.9, 9.8 ± 1.9 mm Hg, and 551.6 ± 36.8 μm, respectively. In the multivariate analysis, CH and CRF values were significantly lower in subjects older than 80 years (-0.56; 95{\%} confidence interval [CI]: -0.89;-0.24); P < 0.001 and -0.48; 95{\%} CI: -0.75;-0.20; P < 0.001, respectively), in subjects having higher ambient UV exposure (-0.50; 95{\%} CI: -0.88;-0.12; P < 0.01; and -0.46; 95{\%} CI: -0.78;-0.13); P < 0.05, respectively), and in subjects with high plasma LDL cholesterol (CH: -0.46; 95{\%} CI: -0.86;-0.03; P < 0.05; and CRF: -0.37; 95{\%} CI: -0.72;-0.008; P < 0.05). Central corneal thickness was significantly higher in former smokers than in never smokers (+11.01; 95{\%} CI: 0.48;21.55; P < 0.05) and was not significantly associated with age, ambient UV exposure, diabetes, or LDL cholesterol. CONCLUSIONS: Biomechanical properties of the cornea are modified by metabolic and lifetime environmental factors, especially UV exposure. The manner these factors may influence onset and progression of ocular diseases or IOP measurements need further investigation.",
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author = "Cedric Schweitzer and Jean-Francois Korobelnik and Mathieu Boniol and Audrey Cougnard-Gregoire and {Le Goff}, Melanie and Florence Malet and Marie-Benedicte Rougier and Marie-Noelle Delyfer and Jean-Francois Dartigues and Cecile Delcourt",
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Schweitzer, C, Korobelnik, J-F, Boniol, M, Cougnard-Gregoire, A, Le Goff, M, Malet, F, Rougier, M-B, Delyfer, M-N, Dartigues, J-F & Delcourt, C 2016, 'Associations of biomechanical properties of the cornea with environmental and metabolic factors in an elderly population: the ALIENOR study' Investigative Ophthalmology and Visual Science, vol. 57, no. 4, pp. 2003-2011. https://doi.org/10.1167/iovs.16-19226

Associations of biomechanical properties of the cornea with environmental and metabolic factors in an elderly population : the ALIENOR study. / Schweitzer, Cedric; Korobelnik, Jean-Francois; Boniol, Mathieu; Cougnard-Gregoire, Audrey; Le Goff, Melanie; Malet, Florence; Rougier, Marie-Benedicte; Delyfer, Marie-Noelle; Dartigues, Jean-Francois; Delcourt, Cecile.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 4, 01.04.2016, p. 2003-2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of biomechanical properties of the cornea with environmental and metabolic factors in an elderly population

T2 - Investigative Ophthalmology and Visual Science

AU - Schweitzer, Cedric

AU - Korobelnik, Jean-Francois

AU - Boniol, Mathieu

AU - Cougnard-Gregoire, Audrey

AU - Le Goff, Melanie

AU - Malet, Florence

AU - Rougier, Marie-Benedicte

AU - Delyfer, Marie-Noelle

AU - Dartigues, Jean-Francois

AU - Delcourt, Cecile

PY - 2016/4/1

Y1 - 2016/4/1

N2 - PURPOSE: The purpose of this study was to assess the associations of biomechanical properties of the cornea with metabolic and environmental factors in an elderly population. METHODS: The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition, and Maladies OculaiRes) study is a population-based study. In 2009-2010, 624 subjects, aged 74 years or more, underwent an eye examination, including intraocular pressure (IOP), central corneal thickness (CCT), and biomechanical properties of the cornea measurements using the Ocular Response Analyzer. Socio-demographic, lifestyle, and medical history data were collected using standardized questionnaires. Mean lifetime ambient ultraviolet (UV) exposure was estimated using residential history and statistics of UV radiation at each location using the Eurosun UV database. RESULTS: Mean age was 82.2 ± 4.3 years. Mean corneal hysteresis (CH), corneal resistance factor (CRF), and CCT were 9.4 ± 1.9, 9.8 ± 1.9 mm Hg, and 551.6 ± 36.8 μm, respectively. In the multivariate analysis, CH and CRF values were significantly lower in subjects older than 80 years (-0.56; 95% confidence interval [CI]: -0.89;-0.24); P < 0.001 and -0.48; 95% CI: -0.75;-0.20; P < 0.001, respectively), in subjects having higher ambient UV exposure (-0.50; 95% CI: -0.88;-0.12; P < 0.01; and -0.46; 95% CI: -0.78;-0.13); P < 0.05, respectively), and in subjects with high plasma LDL cholesterol (CH: -0.46; 95% CI: -0.86;-0.03; P < 0.05; and CRF: -0.37; 95% CI: -0.72;-0.008; P < 0.05). Central corneal thickness was significantly higher in former smokers than in never smokers (+11.01; 95% CI: 0.48;21.55; P < 0.05) and was not significantly associated with age, ambient UV exposure, diabetes, or LDL cholesterol. CONCLUSIONS: Biomechanical properties of the cornea are modified by metabolic and lifetime environmental factors, especially UV exposure. The manner these factors may influence onset and progression of ocular diseases or IOP measurements need further investigation.

AB - PURPOSE: The purpose of this study was to assess the associations of biomechanical properties of the cornea with metabolic and environmental factors in an elderly population. METHODS: The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition, and Maladies OculaiRes) study is a population-based study. In 2009-2010, 624 subjects, aged 74 years or more, underwent an eye examination, including intraocular pressure (IOP), central corneal thickness (CCT), and biomechanical properties of the cornea measurements using the Ocular Response Analyzer. Socio-demographic, lifestyle, and medical history data were collected using standardized questionnaires. Mean lifetime ambient ultraviolet (UV) exposure was estimated using residential history and statistics of UV radiation at each location using the Eurosun UV database. RESULTS: Mean age was 82.2 ± 4.3 years. Mean corneal hysteresis (CH), corneal resistance factor (CRF), and CCT were 9.4 ± 1.9, 9.8 ± 1.9 mm Hg, and 551.6 ± 36.8 μm, respectively. In the multivariate analysis, CH and CRF values were significantly lower in subjects older than 80 years (-0.56; 95% confidence interval [CI]: -0.89;-0.24); P < 0.001 and -0.48; 95% CI: -0.75;-0.20; P < 0.001, respectively), in subjects having higher ambient UV exposure (-0.50; 95% CI: -0.88;-0.12; P < 0.01; and -0.46; 95% CI: -0.78;-0.13); P < 0.05, respectively), and in subjects with high plasma LDL cholesterol (CH: -0.46; 95% CI: -0.86;-0.03; P < 0.05; and CRF: -0.37; 95% CI: -0.72;-0.008; P < 0.05). Central corneal thickness was significantly higher in former smokers than in never smokers (+11.01; 95% CI: 0.48;21.55; P < 0.05) and was not significantly associated with age, ambient UV exposure, diabetes, or LDL cholesterol. CONCLUSIONS: Biomechanical properties of the cornea are modified by metabolic and lifetime environmental factors, especially UV exposure. The manner these factors may influence onset and progression of ocular diseases or IOP measurements need further investigation.

KW - cornea

KW - elderly population

KW - antioxydants

KW - lipides essentiels

KW - nutrition

UR - http://iovs.arvojournals.org/article.aspx?articleid=2516889

U2 - 10.1167/iovs.16-19226

DO - 10.1167/iovs.16-19226

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SP - 2003

EP - 2011

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

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