Abstract
| Language | English |
|---|---|
| Pages | 282-286 |
| Number of pages | 4 |
| Journal | Analyst |
| Volume | 127 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- colloidal silver
- spectroscopy
- electrode
- pyridine
- spectra
- dyes
- sol
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Assessment of silver and gold substrates for the detection of amphetamine sulfate by surface enhanced Raman scattering (SERS). / Faulds, K.; Smith, W.E.; Graham, D.; Lacey, R.J.
In: Analyst, Vol. 127, No. 2, 2002, p. 282-286.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessment of silver and gold substrates for the detection of amphetamine sulfate by surface enhanced Raman scattering (SERS)
AU - Faulds, K.
AU - Smith, W.E.
AU - Graham, D.
AU - Lacey, R.J.
PY - 2002
Y1 - 2002
N2 - Methods of detection of amphetamine sulfate using surface enhanced Raman scattering (SERS) from colloidal suspensions and vapour deposited films of both silver and gold are compared. Different aggregating agents are required to produce effective SERS from silver and gold colloidal suspensions. Gold colloid and vapour deposited gold films give weaker scattering than the equivalent silver substrates when high concentrations of drug are analysed but they also give lower detection limits, suggesting a smaller surface enhancement but stronger surface adsorption. A 10(-5) mol dm(-3) solution (the final concentration after addition of colloid was 10(-6) mol dm(-3)) of amphetamine sulfate was detected from gold colloid with an RSD of 5.4%. 25 mul of the same solution could be detected on a roughened gold film. The intensities of the spectra varied across the film surface resulting in relatively high RSDs. The precision was improved by averaging the scattering from several points on the surface. An attempt to improve the detection limit and precision by concentrating a suspension of gold colloid and amphetamine sulfate in aluminium wells did not give effective quantitation. Thus, positive identification and semi-quantitative estimation of amphetamine sulfate can be made quickly and easily using SERS from suspended gold colloid with the appropriate aggregating agents.
AB - Methods of detection of amphetamine sulfate using surface enhanced Raman scattering (SERS) from colloidal suspensions and vapour deposited films of both silver and gold are compared. Different aggregating agents are required to produce effective SERS from silver and gold colloidal suspensions. Gold colloid and vapour deposited gold films give weaker scattering than the equivalent silver substrates when high concentrations of drug are analysed but they also give lower detection limits, suggesting a smaller surface enhancement but stronger surface adsorption. A 10(-5) mol dm(-3) solution (the final concentration after addition of colloid was 10(-6) mol dm(-3)) of amphetamine sulfate was detected from gold colloid with an RSD of 5.4%. 25 mul of the same solution could be detected on a roughened gold film. The intensities of the spectra varied across the film surface resulting in relatively high RSDs. The precision was improved by averaging the scattering from several points on the surface. An attempt to improve the detection limit and precision by concentrating a suspension of gold colloid and amphetamine sulfate in aluminium wells did not give effective quantitation. Thus, positive identification and semi-quantitative estimation of amphetamine sulfate can be made quickly and easily using SERS from suspended gold colloid with the appropriate aggregating agents.
KW - colloidal silver
KW - spectroscopy
KW - electrode
KW - pyridine
KW - spectra
KW - dyes
KW - sol
UR - http://www.rsc.org/delivery/_ArticleLinking/DisplayArticleForFree.cfm?doi=b107318b&JournalCode=AN
UR - http://dx.doi.org/10.1039/b107318b
U2 - 10.1039/b107318b
DO - 10.1039/b107318b
M3 - Article
VL - 127
SP - 282
EP - 286
JO - Analyst
T2 - Analyst
JF - Analyst
SN - 0003-2654
IS - 2
ER -