Assessment of drug incorporation and release from a novel coronary stent coating

Craig Martin McKittrick; Simon Dixon; Christopher McCormick

Assessment of drug incorporation and release from a novel coronary stent coating

Craig Martin McKittrick, Simon Dixon, Christopher McCormick

Research output: Contribution to conference › Poster › peer-review

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Abstract

The introduction of drug eluting stents (DES) for the treatment of coronary heart disease has significantly reduced in-stent restenosis, however the use of cytostatic agents causes delayed re-endothelialisation of the target vessel. Here we describe the drug release profiles for rapamycin incorporated into a novel acrylic-based polymer designed to promote vascular re-endothelialisation. Understanding drug release from the surface of DES is integral to the stent development process. It is useful for testing the reliability and reproducibility of coatings and for providing insight into mechanisms of drug release.

Original language	English
Publication status	Published - 30 Aug 2015
Event	27th European Conference on Biomaterials - ICE Krakow Congress Centre, Krakow, Poland Duration: 30 Aug 2015 → 3 Sep 2015

Conference

Conference	27th European Conference on Biomaterials
Abbreviated title	ESB 2015
Country	Poland
City	Krakow
Period	30/08/15 → 3/09/15

Keywords

drug delivery
drug release
coronary stent coating
drug eluting stents
DES

Access to Document

McKittrick-etal-ECB-2015-Assessment-of-drug-incorporation-and-release-from-a-novel-coronary-stent-coatingAccepted author manuscript, 392 KB

http://www.esbiomaterials.eu/

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1 Finished

Optimal designs of drug eluting stents
McKee, S., Ainsworth, M., Wadsworth, R. & McCormick, C.
EPSRC (Engineering and Physical Sciences Research Council)
1/04/12 → 30/09/15
Project: Research

Cite this

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title = "Assessment of drug incorporation and release from a novel coronary stent coating",

abstract = "The introduction of drug eluting stents (DES) for the treatment of coronary heart disease has significantly reduced in-stent restenosis, however the use of cytostatic agents causes delayed re-endothelialisation of the target vessel. Here we describe the drug release profiles for rapamycin incorporated into a novel acrylic-based polymer designed to promote vascular re-endothelialisation. Understanding drug release from the surface of DES is integral to the stent development process. It is useful for testing the reliability and reproducibility of coatings and for providing insight into mechanisms of drug release. ",

keywords = "drug delivery, drug release, coronary stent coating, drug eluting stents, DES",

author = "McKittrick, {Craig Martin} and Simon Dixon and Christopher McCormick",

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note = "27th European Conference on Biomaterials , ESB 2015 ; Conference date: 30-08-2015 Through 03-09-2015",

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T1 - Assessment of drug incorporation and release from a novel coronary stent coating

AU - McKittrick, Craig Martin

AU - Dixon, Simon

AU - McCormick, Christopher

PY - 2015/8/30

Y1 - 2015/8/30

N2 - The introduction of drug eluting stents (DES) for the treatment of coronary heart disease has significantly reduced in-stent restenosis, however the use of cytostatic agents causes delayed re-endothelialisation of the target vessel. Here we describe the drug release profiles for rapamycin incorporated into a novel acrylic-based polymer designed to promote vascular re-endothelialisation. Understanding drug release from the surface of DES is integral to the stent development process. It is useful for testing the reliability and reproducibility of coatings and for providing insight into mechanisms of drug release.

AB - The introduction of drug eluting stents (DES) for the treatment of coronary heart disease has significantly reduced in-stent restenosis, however the use of cytostatic agents causes delayed re-endothelialisation of the target vessel. Here we describe the drug release profiles for rapamycin incorporated into a novel acrylic-based polymer designed to promote vascular re-endothelialisation. Understanding drug release from the surface of DES is integral to the stent development process. It is useful for testing the reliability and reproducibility of coatings and for providing insight into mechanisms of drug release.

KW - drug delivery

KW - drug release

KW - coronary stent coating

KW - drug eluting stents

KW - DES

UR - http://www.esbiomaterials.eu/

M3 - Poster

T2 - 27th European Conference on Biomaterials

Y2 - 30 August 2015 through 3 September 2015

ER -

Assessment of drug incorporation and release from a novel coronary stent coating

Abstract

Conference

Keywords

Access to Document

Optimal designs of drug eluting stents

Cite this