Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe

Ioana D. Olaru, Anne Meierkord, Brian Godman, Crispen Ngwenya, Felicity Fitzgerald, Vogai Dondo, Rashida Ferrand, Katharina Kranzer

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Abstract

This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe.
Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated.
A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 – 48 months). Overall antimicrobial consumption was 155.4 DOT / 100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children.
This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.
Original languageEnglish
Number of pages10
JournalJournal of Chemotherapy
Early online date2 Mar 2020
DOIs
Publication statusE-pub ahead of print - 2 Mar 2020

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Keywords

  • antimicrobial resistance (AMR)
  • antimicrobial consumption
  • children
  • antimicrobial stewardship
  • Zimbabwe

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