Assessment of antimicrobial use and prescribing practices among paediatric inpatients in Zimbabwe

Ioana Olaru, Anne Meierkord, Brian Godman, Crispen Ngwenya, Felicity Fitzgerald, Vogai Dondo, Rashida Ferrand, Katharina Kranzer

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Abstract

Background: Antimicrobial resistance threatens our ability to effectively treat infections. A key driver is inappropriate antimicrobial use. There is currently limited information on antibiotic utilisation in Zimbabwe including children. Consequently, the objective of this study was to assess antimicrobial consumption in the paediatric department of a tertiary care public hospital in Zimbabwe. Methods: Clinical records of paediatric inpatients admitted to two general paediatric wards at Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. Results: A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 – 48 months). Overall antimicrobial consumption was 155.4 DOT / 100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. In 111 children, adherence to national guidelines was evaluated and 64 (57.7%) received antimicrobials according to guidelines. For instance, in children admitted with neonatal sepsis, nonadherence (64%) mostly due to prescribing of ceftriaxone or benzylpenicillin and gentamicin versus cloxacillin and gentamicin. Conclusions: There is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines. These findings emphasize the need for antimicrobial stewardship programmes across Zimbabwe and for strengthening diagnostic capacity in low-income settings which is a concern enhancing AMR rates.
Original languageEnglish
Number of pages1
Publication statusAccepted/In press - 21 Nov 2019
EventEuroDURG 2020 - Szeged, Hungary
Duration: 3 Mar 20207 Mar 2020

Conference

ConferenceEuroDURG 2020
CountryHungary
CitySzeged
Period3/03/207/03/20

Keywords

  • antibiotics
  • paediatric
  • Zimbabwe

Cite this

Olaru, I., Meierkord, A., Godman, B., Ngwenya, C., Fitzgerald, F., Dondo, V., Ferrand, R., & Kranzer, K. (Accepted/In press). Assessment of antimicrobial use and prescribing practices among paediatric inpatients in Zimbabwe. Poster session presented at EuroDURG 2020, Szeged, Hungary.