Assessment of adult rat cardiac fibroblast viability following chronic sunitinib treatment

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Abstract

The tyrosine kinase inhibitor sunitinib has dramatically improved cancer therapy in recent years however, this success has been marred by reports of associated cardiotoxicity. The effect of sunitinib on cardiac myocyte function has been extensively studied, yet little is known of wider ranging effects on cardiac non-myocytes. Cardiac fibroblasts (CF) are the most abundant cell type within the heart and are responsible for maintaining cardiac structure via extracellular matrix remodelling and for facilitating synchronised cardiac contraction. Here, we have investigated whether chronic sunitinib treatment adversely affects CF viability.
Original languageEnglish
Pages (from-to)A6-A7
Number of pages2
JournalHeart
Volume105
Issue numbersuppl 4
DOIs
Publication statusPublished - 1 May 2019
Event14th British Society of Cardiovascular Magnetic Resonance Annual Meeting 2019 - Oxford, United Kingdom
Duration: 26 Mar 201927 Mar 2019

Keywords

  • tyrosine kinase inhibitor
  • sunitinib
  • cardiac fibroblast

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