Abstract
| Language | English |
|---|---|
| Pages | 286-289 |
| Number of pages | 3 |
| Journal | Journal of Cataract and Refractive Surgery |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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Assessing the accuracy of intracameral antibiotic preparation for use in cataract surgery. / Lockington, D.; Flowers, H.; Young, D.; Yorston, D.
In: Journal of Cataract and Refractive Surgery, Vol. 36, No. 2, 02.2010, p. 286-289.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessing the accuracy of intracameral antibiotic preparation for use in cataract surgery
AU - Lockington, D.
AU - Flowers, H.
AU - Young, D.
AU - Yorston, D.
PY - 2010/2
Y1 - 2010/2
N2 - PURPOSE: To evaluate 2 local dilution protocols to assess the accuracy and variability of intracameral antibiotic dosage in cataract surgery. SETTING: Tennent Institute of Ophthalmology, Glasgow, United Kingdom. METHODS: Ten ophthalmic operating room nurses from 2 local hospitals participated. Oven-dried analytical grade potassium chloride (KCl) was used as a surrogate for cefuroxime. Solutions intended for intracameral use (1.0 mg in 0.1 mL) were prepared according to the 2 protocols. Twenty samples were obtained for each protocol. Ten analytical chemists also performed both dilutions. Concentrations of KCl in each 0.1 mL sample were analyzed by flame photometry. RESULTS: Thirty samples were obtained for each protocol. The median dose after dilution was 1.17 mg (range 0.62 to 1.77 mg) for protocol 1 and 2.05 mg (range 0.52 to 7.25 mg) for protocol 2. The median was significantly higher for protocol 2 (P < .001). There was also greater variability with protocol 2. CONCLUSIONS: This study shows that the mathematical accuracy of a dilution protocol does not ensure dosage accuracy in the clinical scenario. Inadequate mixing in a 1.0 mL syringe was probably responsible for the inaccuracy of protocol 2, indicating that small-volume syringes should not be used for mixing. However, protocol 1 had an acceptable range of variability. Replication of this study could evaluate other protocols and address concerns regarding the accuracy of intracameral antibiotic preparations.
AB - PURPOSE: To evaluate 2 local dilution protocols to assess the accuracy and variability of intracameral antibiotic dosage in cataract surgery. SETTING: Tennent Institute of Ophthalmology, Glasgow, United Kingdom. METHODS: Ten ophthalmic operating room nurses from 2 local hospitals participated. Oven-dried analytical grade potassium chloride (KCl) was used as a surrogate for cefuroxime. Solutions intended for intracameral use (1.0 mg in 0.1 mL) were prepared according to the 2 protocols. Twenty samples were obtained for each protocol. Ten analytical chemists also performed both dilutions. Concentrations of KCl in each 0.1 mL sample were analyzed by flame photometry. RESULTS: Thirty samples were obtained for each protocol. The median dose after dilution was 1.17 mg (range 0.62 to 1.77 mg) for protocol 1 and 2.05 mg (range 0.52 to 7.25 mg) for protocol 2. The median was significantly higher for protocol 2 (P < .001). There was also greater variability with protocol 2. CONCLUSIONS: This study shows that the mathematical accuracy of a dilution protocol does not ensure dosage accuracy in the clinical scenario. Inadequate mixing in a 1.0 mL syringe was probably responsible for the inaccuracy of protocol 2, indicating that small-volume syringes should not be used for mixing. However, protocol 1 had an acceptable range of variability. Replication of this study could evaluate other protocols and address concerns regarding the accuracy of intracameral antibiotic preparations.
UR - http://dx.doi.org/ 10.1016/j.jcrs.2009.08.034
U2 - 10.1016/j.jcrs.2009.08.034
DO - 10.1016/j.jcrs.2009.08.034
M3 - Article
VL - 36
SP - 286
EP - 289
JO - Journal of Cataract and Refractive Surgery
T2 - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
SN - 0886-3350
IS - 2
ER -