Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction: from optimisation to mole scale

Aymeric P. Colleville, Richard A. J. Horan, Nick C. O. Tomkinson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki-Miyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multi-variate factor optimization. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction and one example was carried out on mole-scale to demonstrate the practicality and scalability of the process
LanguageEnglish
Pages1128–1136
Number of pages9
JournalOrganic Process Research and Development
Volume18
Issue number9
DOIs
Publication statusPublished - 12 Aug 2014

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Scalability
Screening
Salts
salts
Catalysts
optimization
Substrates
safety
screening
chemistry
catalysts
evaluation

Keywords

  • aryldiazonium tetrafluoroborate salts
  • Suzuki–Miyaura reaction
  • mole scale

Cite this

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Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale. / Colleville, Aymeric P.; Horan, Richard A. J.; Tomkinson, Nick C. O.

In: Organic Process Research and Development, Vol. 18, No. 9, 12.08.2014, p. 1128–1136.

Research output: Contribution to journalArticle

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