Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing

Mairi E. Sandison, Daniele Malleo, David Holmes, Richard Berry, Hywel Morgan

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.

Original languageEnglish
Article number47
Pages (from-to)252-257
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5838
DOIs
Publication statusPublished - 9 Dec 2005
EventNanotechnology II - Seville, Spain
Duration: 9 May 200511 May 2005

Keywords

  • lipid bilayers
  • microfluidics
  • rapid fabrication
  • single molecule detection
  • microscopic examination
  • plastic films
  • polymethyl methacrylates
  • thin films
  • fluidic devices

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