Are rate and selectivity correlated in iridium-catalysed hydrogen isotope exchange reactions?

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Abstract

Herein we qualitatively examine the relationship between reaction rate and reaction selectivity in iridium-catalysed hydrogen isotope exchange (HIE) reactions directed by Lewis basic functional groups. We have recently developed a directing group scale that allows semi-quantitative predictions of Lewis base directed selectivity in HIE, formally ranking 'relative rates' determined from a structured set of competition experiments. Here, we show that selectivity and rate are in fact not correlated, but that different types of behaviour emerge in competition experiments and that the observed behaviour can be predicted from our established selectivity scale.

Original languageEnglish
Pages (from-to)5498-5504
Number of pages7
JournalCatalysis Science and Technology
Volume11
Issue number16
Early online date9 Jul 2021
DOIs
Publication statusPublished - 21 Aug 2021

Keywords

  • reaction rate
  • reaction selectivity
  • hydrogen isotope exchange

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