Are glucose profiles well-controlled within the targets recommended by the international diabetes federation in type 2 diabetes?

a meta-analysis of results from continuous glucose monitoring based studies

Aye C Paing, Alison F Kirk, Andrew Collier, Thomas Kubiak, Sebastien F M Chastin

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Abstract

AIMS: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF).

METHODS: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets.

RESULTS: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95% CI, 0.53-1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95% CI, 0.79-2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95% CI, 0.13-1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c <7% and ≥7% (53 mmol/mol) and duration of diabetes <10 years and ≥10 years.

CONCLUSIONS: Independent of HbA1c, fasting glucose and postprandial glucose after breakfast are not well-controlled in type 2 diabetes.

Original languageEnglish
JournalDiabetes Research and Clinical Practice
Early online date3 Nov 2018
DOIs
Publication statusE-pub ahead of print - 3 Nov 2018

Fingerprint

Type 2 Diabetes Mellitus
Meta-Analysis
Glucose
Breakfast
Meals
Fasting
Lunch
Observational Studies
PubMed
MEDLINE
Libraries

Keywords

  • continuous glucose monitoring
  • glucose
  • glucose profiles
  • type 2 diabetes

Cite this

@article{413ed153ff2e45d4b85b840da6cad612,
title = "Are glucose profiles well-controlled within the targets recommended by the international diabetes federation in type 2 diabetes?: a meta-analysis of results from continuous glucose monitoring based studies",
abstract = "AIMS: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF).METHODS: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets.RESULTS: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95{\%} CI, 0.53-1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95{\%} CI, 0.79-2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95{\%} CI, 0.13-1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c <7{\%} and ≥7{\%} (53 mmol/mol) and duration of diabetes <10 years and ≥10 years.CONCLUSIONS: Independent of HbA1c, fasting glucose and postprandial glucose after breakfast are not well-controlled in type 2 diabetes.",
keywords = "continuous glucose monitoring, glucose, glucose profiles, type 2 diabetes",
author = "Paing, {Aye C} and Kirk, {Alison F} and Andrew Collier and Thomas Kubiak and Chastin, {Sebastien F M}",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = "11",
day = "3",
doi = "10.1016/j.diabres.2018.10.010",
language = "English",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",

}

TY - JOUR

T1 - Are glucose profiles well-controlled within the targets recommended by the international diabetes federation in type 2 diabetes?

T2 - a meta-analysis of results from continuous glucose monitoring based studies

AU - Paing, Aye C

AU - Kirk, Alison F

AU - Collier, Andrew

AU - Kubiak, Thomas

AU - Chastin, Sebastien F M

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/11/3

Y1 - 2018/11/3

N2 - AIMS: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF).METHODS: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets.RESULTS: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95% CI, 0.53-1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95% CI, 0.79-2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95% CI, 0.13-1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c <7% and ≥7% (53 mmol/mol) and duration of diabetes <10 years and ≥10 years.CONCLUSIONS: Independent of HbA1c, fasting glucose and postprandial glucose after breakfast are not well-controlled in type 2 diabetes.

AB - AIMS: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF).METHODS: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets.RESULTS: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95% CI, 0.53-1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95% CI, 0.79-2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95% CI, 0.13-1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c <7% and ≥7% (53 mmol/mol) and duration of diabetes <10 years and ≥10 years.CONCLUSIONS: Independent of HbA1c, fasting glucose and postprandial glucose after breakfast are not well-controlled in type 2 diabetes.

KW - continuous glucose monitoring

KW - glucose

KW - glucose profiles

KW - type 2 diabetes

U2 - 10.1016/j.diabres.2018.10.010

DO - 10.1016/j.diabres.2018.10.010

M3 - Review article

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

ER -