Applications of organocatalysed visible-light redox reactions for medicinal chemistry

Michael K. Bogdos, Emmanuel Pinard, John A. Murphy

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The focus of this review is to provide an overview of the field of organocatalysed photoredox chemistry relevant to synthetic medicinal chemistry. Photoredox transformations have been shown to enable key transformations that are important to the pharmaceutical industry. This type of chemistry has also demonstrated a high degree of sustainability, especially when organic dyes can be employed in place of often toxic and environmentally damaging transition metals. The sections are arranged according to the general class of the presented reactions and the value of these methods to medicinal chemistry is considered. An overview of the general characteristics of the photocatalysts as well as some electrochemical data is presented. In addition, the general reaction mechanisms for organocatalysed photoredox transformations are discussed and some individual mechanistic considerations are highlighted in the text when appropriate.
Original languageEnglish
Pages (from-to)2035-2064
Number of pages30
JournalBeilstein Journal of Organic Chemistry
Issue number14
Publication statusPublished - 3 Aug 2018


  • C–H functionalisation
  • heterocycles
  • late-stage functionalisation
  • medicinal chemistry
  • organic dyes
  • organic photocatalysts
  • peptide chemistry
  • photoredox catalysis


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