@inbook{117c5efac194473f8005bd05e6596e7b,
title = "Applications of high throughput chemistry to medicinal chemistry",
abstract = "Rapid exploration of chemical space in Medicinal Chemistry projects is a demanding exercise that requires a steadfast approach and commitment to synthetic strategies that increase the success rate for desired compounds to answer a hypothesis. High-Throughput Experimentation (HTE) has proven to increase this success rate by directly evaluating project intermediates with pharmaceutically relevant building blocks in microscale quantities across a diverse chemical reaction space in parallel. This approach enables both the synthesis route and a blueprint for the scalability of the successful reactions. Herein, we present examples of the application of High-Throughput Chemistry (HTC) to Medicinal Chemistry projects spanning route scouting, parallel synthesis, and HTE coupled with other technologies such as flow and automation.",
keywords = "chemical synthesis, coupling reactions, medicinal chemistry, photochemical reactions, solvents",
author = "Santanilla, {Alexander Buitrago} and Gemma Cook",
year = "2022",
month = nov,
day = "15",
doi = "10.1021/bk-2022-1420.ch001",
language = "English",
isbn = "9780841297555",
volume = "2",
series = "ACS Symposium Series",
publisher = "American Chemical Society",
pages = "3--21",
booktitle = "The Power of High-Throughput Experimentation",
address = "United States",
}