Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 568-574 |
| Number of pages | 7 |
| Journal | PDA Journal of Pharmaceutical Science and Technology |
| Volume | 63 |
| Issue number | 6 |
| Publication status | Published - 30 Nov 2009 |
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Keywords
- surface enhanced Raman spectroscopy
- HPLC
- cleaning verification
- principal component analysis
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Application of surface-enhanced Raman spectroscopy (SERS) for cleaning verification in pharmaceutical manufacture. / Corrigan, D.K.; Cauchi, M.; Piletsky, S.; Mccrossen, S.
In: PDA Journal of Pharmaceutical Science and Technology, Vol. 63, No. 6, 30.11.2009, p. 568-574.Research output: Contribution to journal › Article
TY - JOUR
T1 - Application of surface-enhanced Raman spectroscopy (SERS) for cleaning verification in pharmaceutical manufacture
AU - Corrigan, D.K.
AU - Cauchi, M.
AU - Piletsky, S.
AU - Mccrossen, S.
PY - 2009/11/30
Y1 - 2009/11/30
N2 - Cleaning verification is the process by which pharmaceutical manufacturing equipment is determined as sufficiently clean to allow manufacture to continue. Surface-enhanced Raman spectroscopy (SERS) is a very sensitive spectroscopic technique capable of detection at levels appropriate for cleaning verification. In this paper, commercially available Klarite™ SERS substrates were employed in order to obtain the necessary enhancement of signal for the identification of chemical species at concentrations of 1 to 10 ng/cm2, which are relevant to cleaning verification. The SERS approach was combined with principal component analysis in the identification of drug compounds recovered from a contaminated steel surface.
AB - Cleaning verification is the process by which pharmaceutical manufacturing equipment is determined as sufficiently clean to allow manufacture to continue. Surface-enhanced Raman spectroscopy (SERS) is a very sensitive spectroscopic technique capable of detection at levels appropriate for cleaning verification. In this paper, commercially available Klarite™ SERS substrates were employed in order to obtain the necessary enhancement of signal for the identification of chemical species at concentrations of 1 to 10 ng/cm2, which are relevant to cleaning verification. The SERS approach was combined with principal component analysis in the identification of drug compounds recovered from a contaminated steel surface.
KW - surface enhanced Raman spectroscopy
KW - HPLC
KW - cleaning verification
KW - principal component analysis
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-76049119082&partnerID=40&md5=3cb32cb7d5ce45dcf77da2b96f2ff561
UR - http://journal.pda.org/content/63/6/568.abstract
M3 - Article
VL - 63
SP - 568
EP - 574
JO - PDA Journal of Pharmaceutical Science and Technology
JF - PDA Journal of Pharmaceutical Science and Technology
SN - 1079-7440
IS - 6
ER -