Application of surface-enhanced Raman spectroscopy (SERS) for cleaning verification in pharmaceutical manufacture

D.K. Corrigan, M. Cauchi, S. Piletsky, S. Mccrossen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cleaning verification is the process by which pharmaceutical manufacturing equipment is determined as sufficiently clean to allow manufacture to continue. Surface-enhanced Raman spectroscopy (SERS) is a very sensitive spectroscopic technique capable of detection at levels appropriate for cleaning verification. In this paper, commercially available Klarite™ SERS substrates were employed in order to obtain the necessary enhancement of signal for the identification of chemical species at concentrations of 1 to 10 ng/cm2, which are relevant to cleaning verification. The SERS approach was combined with principal component analysis in the identification of drug compounds recovered from a contaminated steel surface.
Original languageEnglish
Pages (from-to)568-574
Number of pages7
JournalPDA Journal of Pharmaceutical Science and Technology
Volume63
Issue number6
Publication statusPublished - 30 Nov 2009

Keywords

  • surface enhanced Raman spectroscopy
  • HPLC
  • cleaning verification
  • principal component analysis

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