Abstract
Bench-stable complexes of the type [Ir(COD)(NHC)Cl] (NHC = N¬-heterocyclic carbene) have been investigated within the field of hydrogen isotope exchange. By employing a sterically encumbered NHC within such complexes and catalyst loadings of only 5 mol%, moderate to high deuterium incorporations were achieved across a range of aromatic ketones and nitrogen-based heterocycles. The simple and synthetically accessible catalysts reported herein present alternatives to phosphine-based species and increase the available labelling systems with respect to established iridium-based isotope exchange methodologies
Original language | English |
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Pages (from-to) | 451-454 |
Number of pages | 4 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 56 |
Issue number | 9-10 |
Early online date | 19 Jul 2013 |
DOIs | |
Publication status | Published - Jul 2013 |
Keywords
- ortho¬hydrogen isotope exchange
- N-heterocyclic carbene
- deuteration
- iridium