Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

Stefan Senekowitsch; Philipp Schick; Bertil Abrahamsson; Patrick Augustijns; Thomas Gießmann; Hans Lennernäs; Christophe Matthys; Luca Marciani; Xavier Pepin; Alan Perkins; Maximilian Feldmüller; Sarah Sulaiman; Werner Weitschies; Clive G. Wilson; Maura Corsetti; Mirko Koziolek

doi:10.3390/pharmaceutics14040801

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

Stefan Senekowitsch, Philipp Schick, Bertil Abrahamsson, Patrick Augustijns, Thomas Gießmann, Hans Lennernäs, Christophe Matthys, Luca Marciani, Xavier Pepin, Alan Perkins, Maximilian Feldmüller, Sarah Sulaiman, Werner Weitschies, Clive G. Wilson, Maura Corsetti, Mirko Koziolek^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

20 Downloads (Pure)

Abstract

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.

Original language	English
Article number	801
Number of pages	36
Journal	Pharmaceutics
Volume	14
Issue number	4
Early online date	6 Apr 2022
DOIs	https://doi.org/10.3390/pharmaceutics14040801
Publication status	Published - 6 Apr 2022

Keywords

biopharmaceutics
imaging tools
in vivo
pharmacokinetics
aspiration
salivary tracer technique
magnetic marker monitoring
high-resolution manometry
telemetric capsules
scintigraphy
magnetic resonance imaging

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Senekowitsch-etal-Pharmaceutics-2022-Application-of-in-vivo-imaging-techniques-and-diagnostic-toolsFinal published version, 1.46 MBLicence: CC BY 4.0

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Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., Matthys, C., Marciani, L., Pepin, X., Perkins, A., Feldmüller, M., Sulaiman, S., Weitschies, W., Wilson, C. G., Corsetti, M., & Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

@article{3879cd87d739429291cc80ec47318a42,

title = "Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research",

abstract = "Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.",

keywords = "biopharmaceutics, imaging tools, in vivo, pharmacokinetics, aspiration, salivary tracer technique, magnetic marker monitoring, high-resolution manometry, telemetric capsules, scintigraphy, magnetic resonance imaging",

author = "Stefan Senekowitsch and Philipp Schick and Bertil Abrahamsson and Patrick Augustijns and Thomas Gie{\ss}mann and Hans Lennern{\"a}s and Christophe Matthys and Luca Marciani and Xavier Pepin and Alan Perkins and Maximilian Feldm{\"u}ller and Sarah Sulaiman and Werner Weitschies and Wilson, \{Clive G.\} and Maura Corsetti and Mirko Koziolek",

year = "2022",

month = apr,

day = "6",

doi = "10.3390/pharmaceutics14040801",

language = "English",

volume = "14",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI AG",

number = "4",

}

Senekowitsch, S, Schick, P, Abrahamsson, B, Augustijns, P, Gießmann, T, Lennernäs, H, Matthys, C, Marciani, L, Pepin, X, Perkins, A, Feldmüller, M, Sulaiman, S, Weitschies, W, Wilson, CG, Corsetti, M & Koziolek, M 2022, 'Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research', Pharmaceutics, vol. 14, no. 4, 801. https://doi.org/10.3390/pharmaceutics14040801

TY - JOUR

T1 - Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

AU - Senekowitsch, Stefan

AU - Schick, Philipp

AU - Abrahamsson, Bertil

AU - Augustijns, Patrick

AU - Gießmann, Thomas

AU - Lennernäs, Hans

AU - Matthys, Christophe

AU - Marciani, Luca

AU - Pepin, Xavier

AU - Perkins, Alan

AU - Feldmüller, Maximilian

AU - Sulaiman, Sarah

AU - Weitschies, Werner

AU - Wilson, Clive G.

AU - Corsetti, Maura

AU - Koziolek, Mirko

PY - 2022/4/6

Y1 - 2022/4/6

N2 - Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.

AB - Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.

KW - biopharmaceutics

KW - imaging tools

KW - in vivo

KW - pharmacokinetics

KW - aspiration

KW - salivary tracer technique

KW - magnetic marker monitoring

KW - high-resolution manometry

KW - telemetric capsules

KW - scintigraphy

KW - magnetic resonance imaging

U2 - 10.3390/pharmaceutics14040801

DO - 10.3390/pharmaceutics14040801

M3 - Review article

SN - 1999-4923

VL - 14

JO - Pharmaceutics

JF - Pharmaceutics

IS - 4

M1 - 801

ER -

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

Abstract

Keywords

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