Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

Rima McLeod; Michael Kirisits; Craig Roberts; Doug Mack; Ernest Mui; John Barnwell; John  Dame; Jane Carlton; Paul Bartlett; Suzanna Parle

Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

Rima McLeod (Inventor), Michael Kirisits (Inventor), Craig Roberts (Inventor), Doug Mack (Inventor), Ernest Mui (Inventor), John Barnwell (Inventor), John Dame (Inventor), Jane Carlton (Inventor), Paul Bartlett (Inventor), Suzanna Parle (Inventor)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Patent

Abstract

This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

Original language	English
Patent number	US 20030186352 A1
Priority date	23/06/98
Publication status	Published - 2 Oct 2003

Keywords

metabolic pathways
enzymes
peptides
inhibitors
vaccines

Cite this

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title = "Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway",

abstract = "This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.",

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T1 - Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

AU - McLeod, Rima

AU - Kirisits, Michael

AU - Roberts, Craig

AU - Mack, Doug

AU - Mui, Ernest

AU - Barnwell, John

AU - Dame, John

AU - Carlton, Jane

AU - Bartlett, Paul

AU - Parle, Suzanna

PY - 2003/10/2

Y1 - 2003/10/2

N2 - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

AB - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

KW - metabolic pathways

KW - enzymes

KW - peptides

KW - inhibitors

KW - vaccines

M3 - Patent

M1 - US 20030186352 A1

ER -

Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

Abstract

Keywords

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