Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

Rima McLeod (Inventor), Michael Kirisits (Inventor), Craig Roberts (Inventor), Doug Mack (Inventor), Ernest Mui (Inventor), John Barnwell (Inventor), John Dame (Inventor), Jane Carlton (Inventor), Paul Bartlett (Inventor), Suzanna Parle (Inventor)

Research output: Patent

Abstract

This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
LanguageEnglish
Patent numberUS 20030186352 A1
Priority date23/06/98
Publication statusPublished - 2 Oct 2003

Fingerprint

chorismate synthase
Plant Structures
Phosphofructokinases
Peptides
Plastids
Enzymes
Metabolic Networks and Pathways
Vaccines
Antibodies
DNA
Growth
Therapeutics

Keywords

  • metabolic pathways
  • enzymes
  • peptides
  • inhibitors
  • vaccines

Cite this

McLeod, R., Kirisits, M., Roberts, C., Mack, D., Mui, E., Barnwell, J., ... Parle, S. (2003). Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway. (Patent No. US 20030186352 A1).
McLeod, Rima (Inventor) ; Kirisits, Michael (Inventor) ; Roberts, Craig (Inventor) ; Mack, Doug (Inventor) ; Mui, Ernest (Inventor) ; Barnwell, John (Inventor) ; Dame, John (Inventor) ; Carlton, Jane (Inventor) ; Bartlett, Paul (Inventor) ; Parle, Suzanna (Inventor). / Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway. Patent No.: US 20030186352 A1.
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McLeod, R, Kirisits, M, Roberts, C, Mack, D, Mui, E, Barnwell, J, Dame, J, Carlton, J, Bartlett, P & Parle, S 2003, Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway, Patent No. US 20030186352 A1.

Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway. / McLeod, Rima (Inventor); Kirisits, Michael (Inventor); Roberts, Craig (Inventor); Mack, Doug (Inventor); Mui, Ernest (Inventor); Barnwell, John (Inventor); Dame, John (Inventor); Carlton, Jane (Inventor); Bartlett, Paul (Inventor); Parle, Suzanna (Inventor).

Patent No.: US 20030186352 A1.

Research output: Patent

TY - PAT

T1 - Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

AU - McLeod, Rima

AU - Kirisits, Michael

AU - Roberts, Craig

AU - Mack, Doug

AU - Mui, Ernest

AU - Barnwell, John

AU - Dame, John

AU - Carlton, Jane

AU - Bartlett, Paul

AU - Parle, Suzanna

PY - 2003/10/2

Y1 - 2003/10/2

N2 - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

AB - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

KW - metabolic pathways

KW - enzymes

KW - peptides

KW - inhibitors

KW - vaccines

M3 - Patent

M1 - US 20030186352 A1

ER -

McLeod R, Kirisits M, Roberts C, Mack D, Mui E, Barnwell J et al, inventors. Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway. US 20030186352 A1. 2003 Oct 2.