Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway

Rima McLeod (Inventor), Michael Kirisits (Inventor), Craig Roberts (Inventor), Doug Mack (Inventor), Ernest Mui (Inventor), John Barnwell (Inventor), John Dame (Inventor), Jane Carlton (Inventor), Paul Bartlett (Inventor), Suzanna Parle (Inventor)

Research output: Patent


This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
Original languageEnglish
Patent numberUS 20030186352 A1
Priority date23/06/98
Publication statusPublished - 2 Oct 2003


  • metabolic pathways
  • enzymes
  • peptides
  • inhibitors
  • vaccines


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