Abstract
Language | English |
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Patent number | US 20030186352 A1 |
Priority date | 23/06/98 |
Publication status | Published - 2 Oct 2003 |
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Keywords
- metabolic pathways
- enzymes
- peptides
- inhibitors
- vaccines
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Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway. / McLeod, Rima (Inventor); Kirisits, Michael (Inventor); Roberts, Craig (Inventor); Mack, Doug (Inventor); Mui, Ernest (Inventor); Barnwell, John (Inventor); Dame, John (Inventor); Carlton, Jane (Inventor); Bartlett, Paul (Inventor); Parle, Suzanna (Inventor).
Patent No.: US 20030186352 A1.Research output: Patent
TY - PAT
T1 - Apicomplexan chorismate synthase sequences and an inhibitor of the shikimate pathway
AU - McLeod, Rima
AU - Kirisits, Michael
AU - Roberts, Craig
AU - Mack, Doug
AU - Mui, Ernest
AU - Barnwell, John
AU - Dame, John
AU - Carlton, Jane
AU - Bartlett, Paul
AU - Parle, Suzanna
PY - 2003/10/2
Y1 - 2003/10/2
N2 - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
AB - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
KW - metabolic pathways
KW - enzymes
KW - peptides
KW - inhibitors
KW - vaccines
M3 - Patent
M1 - US 20030186352 A1
ER -