Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells

Perle Laté de Laté, Miguel Pineda, Margaret Harnett, William Harnett, Sébastien Besteiro, Gordon Langsley

Research output: Contribution to journalLiterature review

2 Citations (Scopus)
93 Downloads (Pure)

Abstract

Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the degradation of the cell's own components. These intracellular parasites nonetheless seem to present a number of original features compared to their very evolutionarily distant host cells. In mammals and other metazoans, autophagy has been identified as an important contributor to the defence against microbial pathogens. Thus, host autophagy also likely plays a key role in the control of apicomplexan parasites, although its potential manipulation and subversion by intracellular parasites creates a complex interplay in the regulation of host and parasite autophagy. In this mini-review, we summarise current knowledge on autophagy in both parasites and their host cells, in the context of infection by three Apicomplexa: Plasmodium, Toxoplasma, and Theileria.
Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalBiomedical Journal
Volume40
Issue number1
DOIs
Publication statusPublished - 28 Feb 2017

Keywords

  • apicomplexan parasites
  • autophagy
  • Plasmodium
  • Toxoplasma
  • Theileria
  • cell signalling
  • host cell

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