Anxiolytic, antidepressant and antioxidant activity of the methanol extract of Canarium resiniferum leaves

Md Shahin Shah, Mohammed Abu Tayab, Anisur Rahman, Muhammad Nazmul Hasan, Md Saddam Hossain Talukder, A.M. Kafil Uddin, Md Jabed, Md Nazim Uddin Chy, Arkajyoti Paul, Md Masudur Rahman, Talha Bin Emran, Veronique Seidel

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Abstract

Background and aim This study evaluated the anxiolytic, antidepressant, and antioxidant activity of the methanol extract of Canarium resiniferum (MECR) leaves, and determined the total phenolic and flavonoid contents in this extract. Experimental procedure The anxiolytic effect of MECR (100, 200, 400 mg/kg, p.o.) was tested in mice using the elevated plus-maze (EPM) test, the hole-board test (HBT), and the light-dark box (LDB) test. Its antidepressant effect was evaluated in the tail suspension (TST) and the forced swim (FST) tests. The total phenolic (TPC) and flavonoid (TFC) content was measured using standard colorimetric assays. Antioxidant activity was determined using the DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays. Results and conclusion MECR, at all doses, showed dose-dependent anxiolytic activity. At 400 mg/kg, it significantly increased the time spent and number of entries in the open arms (EPM test), the number of head-dips (HBT), and the time spent into the light compartment (LDB) test compared to the control. In the TST and FST, MECR dose-dependently reduced the duration of immobility compared to untreated animals. This was significant for all doses except for 100 mg/kg in the FST model. MECR showed high TPC and TFC (90.94 ± 0.75 mg GAE/g and 51.54 ± 0.78 mg QE/g of dried extract, respectively) and displayed potent activity in the DPPH radical scavenging (IC50 = 177.82 μg/mL) and FRAP assays. These findings indicate that C. resiniferum has the potential to alleviate anxiety and depression disorders, which merits further exploration.
Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalJournal of Traditional and Complementary Medicine
Volume12
Issue number6
Early online date3 Aug 2022
DOIs
Publication statusPublished - Nov 2022

Keywords

  • animal behavioral tests
  • biological activity
  • medicinal plants
  • oxidative stress
  • phytochemicals

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