Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration

Fanny Lemarié, Chun Wai Chang, David Blatchford, Rumelo Amor, Greg Norris, Laurence Tetley, Gail McConnell, Christine Dufès

Research output: Contribution to journalArticle

14 Citations (Scopus)
143 Downloads (Pure)

Abstract

The therapeutic potential of epigallocatechin gallate, a green tea polyphenol with anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a tumor-targeted vesicular formulation of epigallocatechin gallate would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. Transferrin-bearing vesicles encapsulating epigallocatechin gallate were intravenously administered to mice bearing subcutaneous A431 and B16-F10 tumors. The intravenous administration of epigallocatechin gallate encapsulated in transferrin-bearing vesicles resulted in tumor suppression for 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared to controls. Encapsulation of epigallocatechin gallate in transferrin-bearing vesicles is a promising therapeutic strategy.
Original languageEnglish
Pages (from-to)181-192
Number of pages12
JournalNanomedicine
Volume8
Issue number2
Early online date14 Aug 2012
DOIs
Publication statusPublished - 2013

Keywords

  • epigallocatechin gallate
  • cancer therapy
  • green tea
  • tumor targeting
  • transferrin

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