Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration

Fanny Lemarié, Chun Wai Chang, David Blatchford, Rumelo Amor, Greg Norris, Laurence Tetley, Gail McConnell, Christine Dufès

Research output: Contribution to journalArticle

  • 12 Citations

Abstract

The therapeutic potential of epigallocatechin gallate, a green tea polyphenol with anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a tumor-targeted vesicular formulation of epigallocatechin gallate would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. Transferrin-bearing vesicles encapsulating epigallocatechin gallate were intravenously administered to mice bearing subcutaneous A431 and B16-F10 tumors. The intravenous administration of epigallocatechin gallate encapsulated in transferrin-bearing vesicles resulted in tumor suppression for 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared to controls. Encapsulation of epigallocatechin gallate in transferrin-bearing vesicles is a promising therapeutic strategy.
LanguageEnglish
Pages181-192
Number of pages12
JournalNanomedicine
Volume8
Issue number2
Early online date14 Aug 2012
DOIs
StatePublished - 2013

Fingerprint

Bearings (structural)
tea
Polyphenols
Tea
vesicle
suppression
tumor
Intravenous Administration
Tumors
cancer
animal
Transferrin
Neoplasms
encapsulation
Experimental Melanomas
Encapsulation
Animals
epigallocatechin gallate
Squamous Cell Carcinoma
Therapeutics

Keywords

  • epigallocatechin gallate
  • cancer therapy
  • green tea
  • tumor targeting
  • transferrin

Cite this

Lemarié, Fanny ; Chang, Chun Wai ; Blatchford, David ; Amor, Rumelo ; Norris, Greg ; Tetley, Laurence ; McConnell, Gail ; Dufès, Christine. / Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration. In: Nanomedicine. 2013 ; Vol. 8, No. 2. pp. 181-192
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Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration. / Lemarié, Fanny; Chang, Chun Wai; Blatchford, David; Amor, Rumelo; Norris, Greg; Tetley, Laurence; McConnell, Gail; Dufès, Christine.

In: Nanomedicine, Vol. 8, No. 2, 2013, p. 181-192.

Research output: Contribution to journalArticle

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Lemarié F, Chang CW, Blatchford D, Amor R, Norris G, Tetley L et al. Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration. Nanomedicine. 2013;8(2):181-192. Available from, DOI: 10.2217/NNM.12.83