Projects per year
Abstract
This article describes the use of antisolvent addition at high-pressure to aid precipitation and recovery of high-pressure phases to ambient pressure. Paracetamol (PCM) was used as a model system to demonstrate the principle due to the extensive literature of paracetamol at high-pressure and ambient pressure. We have observed that we are able to recover the orthorhombic form of paracetamol to ambient pressure using this technique, although solvent-mediated transformations are a hurdle. During this investigation we observed a new methanol solvate of paracetamol that is simlar in structure to the known form. The methanol solvate is stable to 0.2 GPa before transformation to the orthorhombic form that is known to be the stable form at high pressure.
Original language | English |
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Pages (from-to) | 4437-4443 |
Number of pages | 7 |
Journal | CrystEngComm |
Volume | 21 |
Issue number | 30 |
Early online date | 29 Apr 2019 |
DOIs | |
Publication status | Published - 14 Aug 2019 |
Keywords
- paracetamol
- pressure
- metastable
- antisolvent
- crystallization
- polymorph
- solution-mediated transformation
- high-pressure
Fingerprint
Dive into the research topics of 'Antisolvent addition at extreme conditions'. Together they form a unique fingerprint.Profiles
Projects
- 1 Finished
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Pressure-Induced Nucleation for the Continuous Manufacture of Supramolecular assemblies
Sefcik, J. (Co-investigator), Ter Horst, J. (Co-investigator) & Oswald, I. (Fellow)
EPSRC (Engineering and Physical Sciences Research Council)
1/06/16 → 30/11/22
Project: Research Fellowship
Datasets
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Data for: "Anti-solvent addition at extreme conditions"
Ward, M. (Creator) & Oswald, I. (Creator), University of Strathclyde, 2 May 2019
DOI: 10.15129/92b026cb-deb9-4b77-b875-717849b40fbd
Dataset
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Pharmaceuticals under high pressure
Oswald, I. (Recipient)
10 Sept 2021Activity: Public Engagement and Outreach › Media Participation
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Recovery of high pressure solid forms to ambient pressure
Ward, M. (Speaker)
9 Jul 2019Activity: Talk or presentation types › Oral presentation