Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

Nahoum Guillaume Hsuan Anthony, D. Breen, Joanna Clarke, Gavin Donoghue, Allan J. Drummond, Elizabeth Ellis, Curtis G. Gemmell, Jean-Jacques Helesbeux, Iain. S. Hunter, Abedawn Khalaf, Simon MacKay, J.A. Parkinson, C.J. Suckling, R.D. Waigh

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Abstract

The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increased affinity arising from hydrophobic interactions between minor groove binders and DNA. The introduction of hydrophobic aromatic head groups, including quinolyl and benzoyl derivatives, and of alkenes as linkers led to several strongly active antibacterial compounds with MIC for Staphylococcus aureus, both methicillin-sensitive and -resistant strains, in the range of 0.1−5 μg mL-1, which is comparable to many established antibacterial agents. Antifungal activity was also found in the range of 20−50 μg mL-1 MIC against Aspergillus niger and Candida albicans, again comparable with established antifungal drugs. A quinoline derivative was found to protect mice against S. aureus infection for a period of up to six days after a single intraperitoneal dose of 40 mg kg-1.
Original languageEnglish
Pages (from-to)6116-6125
Number of pages10
JournalJournal of Medicinal Chemistry
Volume50
Issue number24
DOIs
Publication statusPublished - Oct 2007

Keywords

  • antimicrobial lexitropsins
  • amide
  • amidine
  • alkene
  • DNA

Cite this

Anthony, N. G. H., Breen, D., Clarke, J., Donoghue, G., Drummond, A. J., Ellis, E., Gemmell, C. G., Helesbeux, J-J., Hunter, I. S., Khalaf, A., MacKay, S., Parkinson, J. A., Suckling, C. J., & Waigh, R. D. (2007). Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. Journal of Medicinal Chemistry, 50(24), 6116-6125. https://doi.org/10.1021/jm070831g