Antimicrobial agents from the leaf of Struchium sparganophora (Linn) Ktze, Asteraceae.

L.S. Kasim, Valerie Ferro, O.A. Odkoya, A. Drummond, G.E. Ukpo, Veronique Seidel, Alexander Gray, R. Waigh

Research output: Contribution to journalArticlepeer-review

Abstract

Three Antimicrobial agents from the leaf of Struchium sparganophora were isolated by chromatographic methods and characterized. The microbial inhibitory activity of these compounds was investigated against Gram-positive, Gram-negative bacteria and fungi. The antimicrobial activity of some of these compounds was similar in some of the micro-organisms used for the tests except Klebsiella. aerogenes and the fungus Candida albicans where all the compounds showed minimum inhibitory concentration (MIC) values between 50 and 6.25 µg/ml. Luteolin and 3 methyl 2, 6, hexacosedienol significantly inhibited the growth of the two fungi (P<0.05) while vernodalin did not show strong activity against Aspergillus niger with MIC of 100 ug/ml. These compounds contribute to the anti-infective use of this plant in folkloric medicine and also these compounds could be used as natural antimicrobial agents in the food preservation and human health.
Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalJournal of Microbiology and Antimicrobials
Volume3
Issue number1
Publication statusPublished - Jan 2011

Keywords

  • Struchium sparganophora
  • antimicrobial
  • luteolin
  • vernodalin
  • 3 methyl, 2, 6 hexacosedienol

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