Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Rima McLeod (Inventor), Craig Roberts (Inventor), Fiona Roberts (Inventor), Jennifer Johnson (Inventor), Michael Kirisits (Inventor), David Ferguson (Inventor), Russell Lyons (Inventor), Ernest Mui (Inventor), Doug Mack (Inventor), Benjamin Samuel (Inventor), Piotri Gornicki (Inventor), Ellen Zuther (Inventor)

Research output: Patent

Abstract

This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
LanguageEnglish
Patent numberUS 20050142113 A1
Priority date4/05/99
Publication statusPublished - 30 Jun 2005

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Anti-Infective Agents
Parasites
Vaccines
Plant Structures
Phosphofructokinases
Peptides
Plastids
Enzymes
Metabolic Networks and Pathways
Antibodies
DNA
Growth
Therapeutics

Keywords

  • metabolic pathways
  • Apicomplexan growth
  • inhibitor
  • enzymes
  • vaccines

Cite this

McLeod, R., Roberts, C., Roberts, F., Johnson, J., Kirisits, M., Ferguson, D., ... Zuther, E. (2005). Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components. (Patent No. US 20050142113 A1).
McLeod, Rima (Inventor) ; Roberts, Craig (Inventor) ; Roberts, Fiona (Inventor) ; Johnson, Jennifer (Inventor) ; Kirisits, Michael (Inventor) ; Ferguson, David (Inventor) ; Lyons, Russell (Inventor) ; Mui, Ernest (Inventor) ; Mack, Doug (Inventor) ; Samuel, Benjamin (Inventor) ; Gornicki, Piotri (Inventor) ; Zuther, Ellen (Inventor). / Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components. Patent No.: US 20050142113 A1.
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abstract = "This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.",
keywords = "metabolic pathways, Apicomplexan growth, inhibitor, enzymes, vaccines",
author = "Rima McLeod and Craig Roberts and Fiona Roberts and Jennifer Johnson and Michael Kirisits and David Ferguson and Russell Lyons and Ernest Mui and Doug Mack and Benjamin Samuel and Piotri Gornicki and Ellen Zuther",
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McLeod, R, Roberts, C, Roberts, F, Johnson, J, Kirisits, M, Ferguson, D, Lyons, R, Mui, E, Mack, D, Samuel, B, Gornicki, P & Zuther, E 2005, Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components, Patent No. US 20050142113 A1.

Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components. / McLeod, Rima (Inventor); Roberts, Craig (Inventor); Roberts, Fiona (Inventor); Johnson, Jennifer (Inventor); Kirisits, Michael (Inventor); Ferguson, David (Inventor); Lyons, Russell (Inventor); Mui, Ernest (Inventor); Mack, Doug (Inventor); Samuel, Benjamin (Inventor); Gornicki, Piotri (Inventor); Zuther, Ellen (Inventor).

Patent No.: US 20050142113 A1.

Research output: Patent

TY - PAT

T1 - Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

AU - McLeod, Rima

AU - Roberts, Craig

AU - Roberts, Fiona

AU - Johnson, Jennifer

AU - Kirisits, Michael

AU - Ferguson, David

AU - Lyons, Russell

AU - Mui, Ernest

AU - Mack, Doug

AU - Samuel, Benjamin

AU - Gornicki, Piotri

AU - Zuther, Ellen

PY - 2005/6/30

Y1 - 2005/6/30

N2 - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

AB - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

KW - metabolic pathways

KW - Apicomplexan growth

KW - inhibitor

KW - enzymes

KW - vaccines

M3 - Patent

M1 - US 20050142113 A1

ER -

McLeod R, Roberts C, Roberts F, Johnson J, Kirisits M, Ferguson D et al, inventors. Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components. US 20050142113 A1. 2005 Jun 30.