Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

Rima L. McLeod (Inventor), Craig W. Roberts (Inventor), Fiona Roberts (Inventor), Jennifer J. Johnson (Inventor), Michael Kirisits (Inventor), David Ferguson (Inventor), Russell Lyons (Inventor), Russell Lyons (Inventor), Ernest Mui (Inventor), Doug Mack (Inventor), Benjamin Samuel (Inventor), Piotri Gornicki (Inventor), Ellen Zuther (Inventor)

Research output: Patent

Abstract

This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.
LanguageEnglish
Patent numberUS6737237B1
Priority date4/05/99
Publication statusPublished - 18 May 2004

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chorismate synthase
Toxoplasma
Anti-Infective Agents
Parasites
Vaccines
Plant Structures
Phosphofructokinases
Peptides
Plastids
Enzymes
Metabolic Networks and Pathways
Antibodies
DNA
Growth
Therapeutics

Cite this

McLeod, R. L., Roberts, C. W., Roberts, F., Johnson, J. J., Kirisits, M., Ferguson, D., ... Zuther, E. (2004). Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components. (Patent No. US6737237B1).
McLeod, Rima L. (Inventor) ; Roberts, Craig W. (Inventor) ; Roberts, Fiona (Inventor) ; Johnson, Jennifer J. (Inventor) ; Kirisits, Michael (Inventor) ; Ferguson, David (Inventor) ; Lyons, Russell (Inventor) ; Lyons, Russell (Inventor) ; Mui, Ernest (Inventor) ; Mack, Doug (Inventor) ; Samuel, Benjamin (Inventor) ; Gornicki, Piotri (Inventor) ; Zuther, Ellen (Inventor). / Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components. Patent No.: US6737237B1.
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title = "Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components",
abstract = "This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.",
author = "McLeod, {Rima L.} and Roberts, {Craig W.} and Fiona Roberts and Johnson, {Jennifer J.} and Michael Kirisits and David Ferguson and Russell Lyons and Russell Lyons and Ernest Mui and Doug Mack and Benjamin Samuel and Piotri Gornicki and Ellen Zuther",
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McLeod, RL, Roberts, CW, Roberts, F, Johnson, JJ, Kirisits, M, Ferguson, D, Lyons, R, Lyons, R, Mui, E, Mack, D, Samuel, B, Gornicki, P & Zuther, E 2004, Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components, Patent No. US6737237B1.

Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components. / McLeod, Rima L. (Inventor); Roberts, Craig W. (Inventor); Roberts, Fiona (Inventor); Johnson, Jennifer J. (Inventor); Kirisits, Michael (Inventor); Ferguson, David (Inventor); Lyons, Russell (Inventor); Lyons, Russell (Inventor); Mui, Ernest (Inventor); Mack, Doug (Inventor); Samuel, Benjamin (Inventor); Gornicki, Piotri (Inventor); Zuther, Ellen (Inventor).

Patent No.: US6737237B1.

Research output: Patent

TY - PAT

T1 - Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

AU - McLeod, Rima L.

AU - Roberts, Craig W.

AU - Roberts, Fiona

AU - Johnson, Jennifer J.

AU - Kirisits, Michael

AU - Ferguson, David

AU - Lyons, Russell

AU - Lyons, Russell

AU - Mui, Ernest

AU - Mack, Doug

AU - Samuel, Benjamin

AU - Gornicki, Piotri

AU - Zuther, Ellen

PY - 2004/5/18

Y1 - 2004/5/18

N2 - This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.

AB - This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.

M3 - Patent

M1 - US6737237B1

ER -

McLeod RL, Roberts CW, Roberts F, Johnson JJ, Kirisits M, Ferguson D et al, inventors. Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components. US6737237B1. 2004 May 18.