Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

Rima L. McLeod (Inventor), Craig W. Roberts (Inventor), Fiona Roberts (Inventor), Jennifer J. Johnson (Inventor), Michael Kirisits (Inventor), David Ferguson (Inventor), Russell Lyons (Inventor), Russell Lyons (Inventor), Ernest Mui (Inventor), Doug Mack (Inventor), Benjamin Samuel (Inventor), Piotri Gornicki (Inventor), Ellen Zuther (Inventor)

Research output: Patent


This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.
Original languageEnglish
Patent numberUS6737237B1
Priority date4/05/99
Publication statusPublished - 18 May 2004

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