Antimicrobial agents diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Rima L. W. McLeod (Inventor), Craig W. Roberts (Inventor), Fiona Roberts (Inventor), Jennifer J. Johnson (Inventor), Laurens Mets (Inventor)

Research output: Patent

Abstract

This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
Original languageEnglish
Patent numberUS6699654B1
Priority date23/06/98
Publication statusPublished - 2 Mar 2004

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