This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
|Publication status||Published - 2 Jun 1999|
Johnson, J. J., McLeod, R. L. W., Mets, L., Roberts, C. W., & Roberts, F. (1999). Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components. (Patent No. EP0918868A2).