Antimicrobial activity of pentacyclic triterpenes isolated from African combretaceae

D.R. Katerere, A. Gray, R.J. Nash, R.D. Waigh

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.
Original languageEnglish
Pages (from-to)81-99
Number of pages19
JournalPhytochemistry
Volume63
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • pentacyclic tritepenes
  • novel glycosidic derivatives
  • spectroscopic methods
  • Staphylococcus aureus

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